Highlights
- •Postprandial glicentin and GLP-1 levels are lower in patients with diabetes.
- •Progression to diabetes shows reduction of postprandial glicentin and GLP-1.
- •Glucagon concentrations correlate with visceral fat mass and liver fat%
- •Changes in glicentin and GLP-1 levels correlate with changes in beta cell function.
- •Incretin concentrations in prediabetic state cannot predict future glycaemic traits.
Abstract
Aims
Weaimed to compare theconcentrations of GLP-1, glucagon and GIP (established regulators
of glucose homeostasis) and glicentin (emerging new metabolic marker)during an OGTT
in patients with normal glucose tolerance (NGT), prediabetes and diabetes at onset,
and one-year before, when all had prediabetes.
Methods
GLP-1, glucagon, GIP and glicentin concentrations were measured and compared with
markers of body composition, insulin sensitivity and β-cell function at a 5-timepoint
OGTT in 125 subjects (30 diabetes, 65 prediabetes, 30 NGT) and in 106 of them one-year
before, when all had prediabetes.
Results
At baseline, when all subjects were in prediabetic state, hormonal levels did not
differ between groups. One year later, patients progressing to diabetes had lower
postprandial increases of glicentin and GLP-1, lower postprandial decrease of glucagon,
and higher levels of fasting GIP compared to patients regressing to NGT. Changes in
glicentin and GLP-1 AUC within this year correlated negatively with changes in Glucose
AUC of OGTT and with changes in markers of beta cell function.
Conclusion
Incretins, glucagon and glicentin profiles in prediabetic state cannot predict future
glycemic traits, but prediabetes progressing to diabetes is accompanied by deterioration
of postprandial increases of GLP-1 and glicentin.
Keywords
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Article info
Publication history
Accepted:
March 16,
2023
Received in revised form:
March 1,
2023
Received:
January 26,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier B.V. All rights reserved.
