Abstract
Aims
To uncover novel candidate metabolomic and lipidomic biomarkers in newly-diagnosed
type 1 diabetes (T1DM) after achieving optimal glucose control.
Methods
Comprehensive lipidomic and metabolomic analysis was performed in serum of 12 adults
with T1DM at onset and after achieving optimal glycemic control (HbA1c < 7 %) (after
2–6 months).
Results
After intensive therapy, subjects (mean age 25.2 years, 58.3 % men) showed decreases
in blood glucose (p < 0.001), HbA1c [11.5 % (9.2–13.4) to 6.2 % (5.2 – 6.7); p < 0.001]
and changes in 51 identified lipids. Among these changes, we found that triglycerides
(TG) containing medium chain fatty acids (TG45:0, TG47:1), sphingomyelins (SM) (SM(d18:2/20:0),
SM42:4)), and phosphatidylcholines (PC) (PC(O-26:2), PC(O-30:0), PC(O-32:0), PC(O-42:6),
PC(O-44:5), PC(O-38:3), PC(O-33:0), PC(O-46:8), PC(O-44:6), PC(O-40:3), PC(O-42:4),
PC(O-46:7), PC(O-46:6), PC(O-44:5), PC(O-42:3), PC(O-44:4)) decreased; whereas PC(35:1),
PC(37:1) and TG containing longer chain fatty acids (TG(52:1), TG(55:7), TG(51:2),
TG(53:3), TG52:2), TG(53:2), TG(57:3), TG(61:3), TG(61:2) increased. Further, dihydro
O-acylceramide (18:1/18:0/16:0), diacylglycerophosphoethanolamine (PE(34:1)), diacylglycerophosphoinositol
(PI(38:6), and dihydrosphingomyelins (dihydroSM(36:0), dihydroSM(40:0), dihydroSM(41:0),
dihydroSM(42:0)) increased. Uric acid, mannitol, and mannitol-1-acetate levels also
increased.
Conclusions
Our data uncovered potential favorable changes in the metabolism of glycerophospholipids,
glycerolipids, and sphingolipids in new-onset T1DM after achieving optimal glycemic
control. Further research on their potential role in developing diabetes-related complications
is needed.
Keywords
Abbreviations:
BMI (body mass index), CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration), CVD (cardiovascular disease), DBP (diastolic blood pressure), eGFR (estimated glomerular filtration rate), FCs (fold-changes), HbA1c (glycosylated hemoglobin), HDL-C (high-density lipoprotein cholesterol), LDL-C (low-density lipoprotein cholesterol), PC (phosphatidylcholines), SBP (systolic blood pressure), SM (sphingomyelin), T1DM (type 1 diabetes mellitus), TG (triglycerides)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 16, 2023
Accepted:
February 10,
2023
Received in revised form:
February 8,
2023
Received:
November 28,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
