Highlights
- •Cumulative muscle strength was associated with low risk of diabetes in ageing adults.
- •Cumulative systolic rather diastolic blood pressure mediated theses associations.
- •Cumulative grip strength related to favorable cardiometabolic health at follow-up.
- •Emphasis on long-term exposure to muscle strength for health wellbeing is desirable.
Abstract
Aims
Previous studies assessing the association of muscle strength with risk of diabetes
have seldomly accounted for the cumulative exposure over time. This study examined
the association of 4-year cumulative muscle strength with risk of diabetes in middle-aged
and older adults.
Methods
We included participants without diabetes, who had 3 repeated measurements of muscle
strength, which was assessed by grip strength (normalized by body-weight) and chair-rising
time, over 4 years. Cumulative muscle strength was calculated based on trapezoid rule.
Logistic regression analysis and mediation analysis for cumulative blood pressure
were performed.
Results
We included 3731 and 3799 participants with data on cumulative grip strength and cumulative
chair-rising time, respectively. The odds of diabetes were gradually reduced with
increments in cumulative grip strength or decrements in cumulative chair-rising time,
with the corresponding odds ratio being 0.79 and 0.89 per 1 standard deviation change
after multivariable-adjustment. Cumulative systolic blood pressure mediated 10.8%
and 14.2% of the associations of diabetes with cumulative grip strength and cumulative
chair-rising time, respectively. Cumulative grip strength also correlated inversely
with blood pressure, glycemia, and inflammation.
Conclusions
Higher cumulative muscle strength was associated with lower risk of diabetes and better
cardiometabolic health in middle-aged and older Chinese adults.
Keywords
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References
- IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045.Diabetes Res Clin Pract. 2022; 183109119
- Anti-diabetic drugs and sarcopenia: emerging links, mechanistic insights, and clinical implications.J Cachexia Sarcopenia Muscle. 2021; 12: 1368-1379
- Diabetes-multimorbidity combinations and disability among middle-aged and older adults.J Gen Intern Med. 2019; 34: 944-951
- Mechanisms of sarcopenia of aging.J Endocrinol Invest. 1999; 22: 95-105
- Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators.J Cachexia Sarcopenia Muscle. 2022; 13: 1177-1196
- Low grip strength predicts incident diabetes among mid-life women: the Michigan study of Women’s health across the nation.Age Ageing. 2018; 47: 685-691
- Cardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and meta-analysis.Diabetologia. 2019; 62: 1129-1142
- Muscle grip strength predicts incident type 2 diabetes: population-based cohort study.Metabolism. 2016; 65: 883-892
- Risk factors for developing diabetes after 3 years among community-dwelling elderly with impaired fasting glucose.J Diabetes. 2019; 11: 107-114
- Association of Muscle Mass, area, and strength with incident diabetes in older adults: the health ABC study.J Clin Endocrinol Metab. 2016; 101: 1847-1855
- Changes in objectively-measured physical capability over 4-year, risk of diabetes, and glycemic control in older adults: the China health and retirement longitudinal study.Diabetes Res Clin Pract. 2022; 184109186
- Aging, physical activity, and diabetic complications related to loss of muscle strength in patients with type 2 diabetes.Phys Ther Res. 2018; 21: 33-38
- Age and aging effects on blood pressure: 15 years follow-up of Tehran lipid and glucose study.J Clin Hypertens (Greenwich). 2021; 23: 1205-1211
- Resistance training to reduce resting blood pressure and increase muscle strength in users and non-users of anti-hypertensive medication: a meta-analysis.Clin Exp Hypertens. 2021; 43: 474-485
- Longitudinal physical performance and blood pressure changes in older women: findings form the women’s health initiative.Arch Gerontol Geriatr. 2022; 98104576
- Grip strength and the metabolic syndrome: findings from the Hertfordshire cohort study.QJM. 2007; 100: 707-713
- Association of Cumulative Systolic Blood Pressure with Long-Term Risk of cardiovascular disease and healthy longevity: findings from the lifetime risk pooling project cohorts.Hypertension. 2021; 77: 347-356
- Time-cumulated blood pressure exposure and incident impairment of glucose tolerance and diabetes mellitus.BMC Cardiovasc Disord. 2017; 17: 106
- Cohort profile: the China health and retirement longitudinal study (CHARLS).Int J Epidemiol. 2014; 43: 61-68
- Muscle strength and prediabetes progression and regression in middle-aged and older adults: a prospective cohort study.J Cachexia Sarcopenia Muscle. 2022; 13: 909-918
- A body shape index significantly predicts MRI-defined abdominal adipose tissue depots in non-obese Asian Indians with type 2 diabetes mellitus.BMJ Open Diabetes Res Care. 2020; : 8
- Venous blood-based biomarkers in the China health and retirement longitudinal study: rationale, design, and results from the 2015 wave.Am J Epidemiol. 2019; 188: 1871-1877
- Muscle weakness thresholds for prediction of diabetes in adults.Sports Med. 2016; 46: 619-628
- The association between muscle weakness and incident diabetes in older Mexican Americans.J Am Med Dir Assoc. 2017; 18: e7-e12
- Association of metabolic score for insulin resistance and its 6-year change with incident type 2 diabetes mellitus.J Diabetes. 2021; 13: 725-734
- Introduction to mediation analysis with structural equation modeling.Shanghai Arch Psychiatry. 2013; 25: 390-394
- Grip strength: an indispensable biomarker for older adults.Clin Interv Aging. 2019; 14: 1681-1691
- Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies.Nat Rev Endocrinol. 2018; 14: 513-537
- Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: a systematic review and meta-analysis.World J Diabetes. 2019; 10: 311-323
- The influence of resting blood pressure on muscle strength in healthy adults.Blood Press Monit. 2018; 23: 185-190
- Higher blood pressure is associated with higher handgrip strength in the oldest old.Am J Hypertens. 2011; 24: 83-89
- Hand-grip dynamometry predicts future outcomes in aging adults.J Geriatr Phys Ther. 2008; 31: 3-10
- Sex difference in development of diabetes and cardiovascular disease on the way from obesity and metabolic syndrome.Metabolism. 2005; 54: 800-808
- Committee of clinical practice guideline of Korean diabetes a. screening for prediabetes and diabetes in Korean nonpregnant adults: a position statement of the Korean Diabetes Association, 2022.Diabetes Metab J. 2022; 46: 819-826
- The impact of the National Health Program on diabetes incidence among working-age men with prediabetes: a regression discontinuity analysis of a nation-wide database in Japan.Diabetes Res Clin Pract. 2022; 189109946
- Diabetes fact sheets in Korea, 2020: an appraisal of current status.Diabetes Metab J. 2021; 45: 1-10
- Association between cardiorespiratory fitness and risk of type 2 diabetes: a meta-analysis.Obesity (Silver Spring). 2019; 27: 315-324
- Grip strength is not associated with incident type 2 diabetes mellitus in healthy adults: the CoLaus study.Diabetes Res Clin Pract. 2017; 132: 144-148
Article info
Publication history
Published online: February 02, 2023
Accepted:
January 30,
2023
Received in revised form:
January 15,
2023
Received:
December 19,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
