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Association between uric acid levels and incidence of type 2 diabetes: Population-based Panasonic cohort study 11

  • Genki Kobayashi
    Affiliations
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
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  • Hiroshi Okada
    Correspondence
    Corresponding author at: Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
    Affiliations
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan

    Department of Diabetes and Endocrinology, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi 570-8540, Japan
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  • Masahide Hamaguchi
    Affiliations
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
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  • Kazushiro Kurogi
    Affiliations
    Department of Health Care Center, Panasonic Health Insurance Organization, 5-55 Sotojima-cho, Moriguchi 570-8540, Japan
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  • Hiroaki Murata
    Affiliations
    Department of Orthopaedic Surgery, Matsushita Memorial Hospital, 5-55 Sotojima-cho, Moriguchi 570-8540, Japan
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  • Masato Ito
    Affiliations
    Department of Health Care Center, Panasonic Health Insurance Organization, 5-55 Sotojima-cho, Moriguchi 570-8540, Japan
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  • Michiaki Fukui
    Affiliations
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
    Search for articles by this author
Published:November 21, 2022DOI:https://doi.org/10.1016/j.diabres.2022.110179

      Highlights

      • The relationship between serum uric acid levels and incident type 2 diabetes remains controversial.
      • In men, serum uric acid levels were not associated with incident type 2 diabetes.
      • In women, serum uric acid levels were associated with incident type 2 diabetes.

      Abstract

      Aims

      This cohort study intended to assess the association between serum uric acid levels and incidence of type 2 diabetes in a Japanese population.

      Methods

      Individuals who participated a medical health checkup program carried out by Panasonic Corporation from 2008 to 2018 were included in this study. A total of 122,123 participants (92,718 men and 29,405 women) were included. During the research period, 6,386 participants developed type 2 diabetes.

      Results

      Multivariate analysis showed that, in men, serum uric acid levels were not significantly associated with incident type 2 diabetes after adjusting for diabetes risk factors. However, in women, the risk of type 2 diabetes incidence was higher in the group with uric acid levels 5.1–6.0 mg/dL (hazard ratio, 2.01 [95% confidence interval: 1.26–3.42]) or >6.1 mg/dL (hazard ratio, 1.85 [95% confidence interval: 1.11–3.22]) than in the group with uric acid levels ≤3 mg/dL. Furthermore, in women, the area under the receiver operating characteristic curve and optimized cut-off values of uric acid for the incidence of type 2 diabetes at 10 years were 0.720 and 4.8 mg/dL, respectively.

      Conclusions

      Serum uric acid levels were associated with incident type 2 diabetes in Japanese women but not in Japanese men.

      Keywords

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