In the present issue, Wijkman et al provide compelling evidence that N-terminal prohormone type B natriuretic peptide (NT-proBNP) has prognostic value for
predicting mortality in patients with type 2 diabetes (T2D)[
[1]
]. In a community-based cohort of 5861 individuals, followed for median of 7.2 years,
they showed that NT-proBNP alone could discriminate the risk of mortality better than
conventional risk factors among individuals with T2D [
- Wijkman M.O.
- Claggett B.L.
- Malachias M.V.B.
- Vaduganathan M.
- Ballantyne C.M.
- Kitzman D.W.
- et al.
Importance of NT-proBNP and conventional risk factors for prediction of death in older
adults with and without diabetes mellitus– a report from the Atherosclerosis Risk
in Communities (ARIC) study.
Diab Res Clin Practice. 2022; (In Press)
[1]
]. Remarkably, the prognostic value of NT-proBNP was similar to that achieved with
the Pooled Cohorts Equation, which includes all the following variables: age, sex,
black race, total cholesterol, high-density lipoprotein cholesterol, systolic blood
pressure, use of antihypertensive medication, and smoking status, plus the estimated
glomerular filtration rate, high sensitivity-C-reactive protein level, and high sensitivity-troponin
T level. This evidence is nicely summarized in Figure 1 and highlights the extremely
high prognostic value of NT-proBNP in patients with diabetes. In patients without
T2D, the discriminatory ability of NT-proBNP was similar to that observed with the
Pooled Cohorts Equation (1).- Wijkman M.O.
- Claggett B.L.
- Malachias M.V.B.
- Vaduganathan M.
- Ballantyne C.M.
- Kitzman D.W.
- et al.
Importance of NT-proBNP and conventional risk factors for prediction of death in older
adults with and without diabetes mellitus– a report from the Atherosclerosis Risk
in Communities (ARIC) study.
Diab Res Clin Practice. 2022; (In Press)
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References
- Importance of NT-proBNP and conventional risk factors for prediction of death in older adults with and without diabetes mellitus– a report from the Atherosclerosis Risk in Communities (ARIC) study.Diab Res Clin Practice. 2022; (In Press)
- Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people.Lancet Diabetes Endocrinol. 2015 Feb; 3: 105-113
- Dysglycaemia and high natriuretic peptides: the prelude to heart failure.Eur J Heart Fail. 2022 Feb; 24: 254-256
- Elevated plasma levels of Nt-proBNP in patients with type 2 diabetes without overt cardiovascular disease.Diabetes Care. 2004 Aug; 27: 1929-1935
- Heart Failure: An Underappreciated Complication of Diabetes. A Consensus Report of the American Diabetes Association.Diabetes Care. 2022; 45: 1670-1690
- The 'Peptide for Life' Initiative: a call for action to provide equal access to the use of natriuretic peptides in the diagnosis of acute heart failure across Europe.Eur J Heart Fail. 2021 Sep; 23: 1432-1436
- 'Peptide for Life' in primary care: work in progress.Eur Heart J. 2021; : ehab829https://doi.org/10.1093/eurheartj/ehab829
- Biomarkers of preclinical ventricular dysfunction in type 2 diabetes mellitus.Rev Esp Cardiol (Engl Ed). 2022; (S1885-5857(22)00178-5)
Article info
Publication history
Published online: November 18, 2022
Accepted:
November 14,
2022
Received:
November 14,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
