Abstract
Objective
The aim is to assess the relationship between the hemoglobin glycation index(HGI)
and dietary patterns, and investigates whether inflammation and oxidative stress mediate
the relationship.
Methods
Cross-sectional data were collected from 453 dwellers in a Chinese rural community.
Diet was assessed using 24 h food recalls. Based on the energy intake ratio from three
macronutrients, dietary patterns were identified by cluster analysis. The HGI was
defined as the observed HbA1c minus predicted HbA1c. Indicators of inflammation and
oxidative stress were assessed.
Result
3 dietary patterns were clustered, namely “fat(n = 100)”, “balance(n = 186)” and “carbohydrate(n = 167)”.
The fat dietary patterns had lower HGI than the other two dietary patterns. TNFα was
higher in the carbohydrate dietary pattern. Linear regression analysis suggested that
the carbohydrate dietary pattern was correlated with higher HGI levels(β = 0.204,95 %CI(0.071,0.338)),
compared with the fat dietary pattern. The relationship disappeared after accounting
for biomarkers of inflammation and oxidative stress. Mediation analyses indicated
that TNFα might explain for 19.15 % effects of the carbohydrate dietary pattern on
HGI, compared with the fat dietary pattern.
Conclusion
The carbohydrate dietary pattern had positive associations with HGI and TNFα. TNFα
partly mediated the relationship between dietary patterns and HGI.
Keywords
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Article info
Publication history
Published online: November 11, 2022
Accepted:
November 8,
2022
Received in revised form:
May 15,
2022
Received:
September 26,
2021
Identification
Copyright
© 2022 Published by Elsevier B.V.
