Abstract
Aims
We sought to quantify the burden and diversity of reasons for hospital admission amongst
Australians with type 2 diabetes compared to the general population.
Methods
We linked Australians aged 15 and above with type 2 diabetes on the National Diabetes
Services Scheme (n = 456,265) to hospital admission data to determine hospitalisation
risks at ICD-10 three-digit diagnosis level for 2010–2017. We performed Poisson regression
to determine the hospitalisation burden of each diagnosis among those with diabetes
compared to the general population and reported excess annual hospitalisations per
100,000 people with diabetes.
Results
Australians with diabetes were at increased risk of hospitalisation for most conditions.
In addition to traditional complications including heart failure, other conditions
such as mental health disorders and anaemias were major causes for excess hospitalisation,
compared to the general population. The leading cause of excess hospitalisation in
women with diabetes was iron deficiency anaemia, responsible for 558 excess annual
hospitalisations per 100,000 women with diabetes. In men, the leading cause was cellulitis,
responsible for 364 excess annual hospitalisations per 100,000.
Conclusions
The diseases responsible for excess hospitalisations in type 2 diabetes are more diverse
than previously recognised. This may need to be reflected in changes to diabetes management.
Keywords
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References
- The changing face of diabetes complications.Lancet Diabetes Endocrinol. 2016; 4: 537-547https://doi.org/10.1016/S2213-8587(16)30010-9
- Global trends in diabetes complications: a review of current evidence.Diabetologia. 2019; 62: 3-16https://doi.org/10.1007/s00125-018-4711-2
- The burden and risks of emerging complications of diabetes mellitus.Nat Rev Endocrionol. 2022; https://doi.org/10.1038/s41574-022-00690-7
- Trends in leading causes of hospitalisation of adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records.Lancet Diabetes Endocrinol. 2022; 10: 46-57https://doi.org/10.1016/S2213-8587(21)00288-6
- Impact of diabetes on hospital admission and length of stay among a general population aged 45 year or more: a record linkage study.BMC Health Serv Res. 2015; 15: 12https://doi.org/10.1186/s12913-014-0666-2
- Trends in the Incidence of Hospitalization for Major Diabetes-Related Complications in People With Type 1 and Type 2 Diabetes in Australia, 2010–2019.Diabetes Care. 2022; https://doi.org/10.2337/dc21-2268
Australian Institute of Health and Welfare. National Hospitals Data Collection. 2021. https://www.aihw.gov.au/about-our-data/our-data-collections/national-hospitals-data-collection (accessed 28 October 2021).
Australian Bureau of Statistics. National, state and territory population. 2021. https://www.abs.gov.au/statistics/people/population/national-state-and-territory-population/latest-release#data-download (accessed 1 February 2022).
- Long-Term Complications of Diabetes Mellitus.New Engl J Med. 1993; 328: 1676-1685https://doi.org/10.1056/NEJM199306103282306
- Influence of diabetes mellitus and glycaemic control on the characteristics and outcome of common infections.Diabet Med. 1996; 13: 457-463https://doi.org/10.1002/(SICI)1096-9136(199605)13:5<457::AID-DIA83>3.0.CO;2-T
- Diabetic cataracts: Mechanisms and management.Diabetes Metab Res Rev. 2010; 26: 172-180https://doi.org/10.1002/dmrr.1075
- Type 2 diabetes and incidence of cardiovascular diseases: A cohort study in 1·9 million people.Lancet Diabetes Endocrinol. 2015; 3: 105-113https://doi.org/10.1016/S2213-8587(14)70219-0
- Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America: This statement does not represent an update of the 2017 ACC/AHA/HFSA heart failure guideline update.Circulation. 2019; 140: e294-e324https://doi.org/10.1161/cir.0000000000000691
- Trends in the Incidence of Hospitalization for Major Diabetes-Related Complications in People With Type 1 and Type 2 Diabetes in Australia, 2010–2019.Diabetes Care. 2022; 45: 789-797https://doi.org/10.2337/dc21-2268
- Persistent disparities in diabetes medication receipt by socio-economic disadvantage in Australia.Diabet Med. 2022; 39: e14898
- Temporal trends in rates of infection-related hospitalisations in Hong Kong people with and without diabetes, 2001–2016: a retrospective study.Diabetologia. 2021; 64: 109-118https://doi.org/10.1007/s00125-020-05286-2
- Diabetes and the risk of hospitalisation for infection: the Atherosclerosis Risk in Communities (ARIC) study.Diabetologia. 2021; https://doi.org/10.1007/s00125-021-05522-3
- Infections in patients with diabetes mellitus: A review of pathogenesis. Indian.J Endocrinol Metab. 2012; 16 Suppl 1(Suppl1): S27-S36https://doi.org/10.4103/2230-8210.94253
- Cellulitis: current insights into pathophysiology and clinical management.Neth J Med. 2017; 75: 366-378
- Association Between Antipsychotic Medication Use and Diabetes.Curr Diabetes Rep. 2019; 19https://doi.org/10.1007/s11892-019-1220-8
- Diabetes and Schizophrenia Curr Diabetes Rep. 2016; 16: 16https://doi.org/10.1007/s11892-015-0704-4
- Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies.Diabetes Res Clin Pract. 2013; 99: 98-104https://doi.org/10.1016/j.diabres.2012.11.022
- The relationship between bipolar disorder and type 2 diabetes: more than just co-morbid disorders.Ann Med. 2013; 45: 171-181https://doi.org/10.3109/07853890.2012.687835
- Criterion and predictive validity of the diagnosis of adjustment disorder: a prospective study of youths with new-onset insulin-dependent diabetes mellitus.Am J Psychiatry. 1995; 152: 523-528https://doi.org/10.1176/ajp.152.4.523
- Diabetes Distress Among Adolescents with Type 1 Diabetes: a Systematic Review.Curr Diabetes Rep. 2016; 16: 1-14https://doi.org/10.1007/s11892-015-0694-2
- Iron deficiency anemia and glucose metabolism.Acta Biomed. 2017; 88: 112-118https://doi.org/10.23750/abm.v88i1.6049
- Proton pump inhibitors are associated with incident type 2 diabetes mellitus in a prospective population-based cohort study.Br J Clin Pharmacol. 2021; https://doi.org/10.1111/bcp.15182
- Proton Pump Inhibitor and Histamine-2 Receptor Antagonist Use and Iron Deficiency.Gastroenterology. 2017; 152: 821-829.e821https://doi.org/10.1053/j.gastro.2016.11.023
- Metabolic asthma: is there a link between obesity, diabetes, and asthma?.Immunol Allergy Clinics North Am. 2014; 34: 777-784https://doi.org/10.1016/j.iac.2014.07.002
- Gallstone Disease and the Risk of Type 2 Diabetes.Sci Rep. 2017; 7: 15853https://doi.org/10.1038/s41598-017-14801-2
- Diabetes mellitus and the risk of nephrolithiasis.Kidney Int. 2005; 68: 1230-1235https://doi.org/10.1111/j.1523-1755.2005.00516.x
- Diabetes mellitus and risk of prostate cancer: A meta-analysis.Diabetologia. 2004; 47: 1071-1078https://doi.org/10.1007/s00125-004-1415-6
- Diabetes mellitus and thoracic aortic disease: are people with diabetes mellitus protected from acute aortic dissection?.J Am Heart Assoc. 2012; 1: e001404
- Inguinal Hernia: classification, diagnosis and treatment–classic, traumatic and Sportsman's hernia.Eur J Med Res. 2005; 10: 121-134
Article info
Publication history
Published online: November 08, 2022
Accepted:
October 28,
2022
Received in revised form:
October 26,
2022
Received:
August 14,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
