Abstract
Aims
The management of diabetic foot ulcers is a challenging issue due to the pathophysiological
background, delay in healing, and prevalence of diabetes. The purpose of this study
was to compare the therapeutic effects of the three methods of diabetic wound care:
surgical debridement and dressing, dressing with dehydrated amnion powder, and dressing
with platelet-derived growth factor gel.
Methods
In this multi-arm parallel-group randomized trial, 243 patients with a minimum 4-week
medical history of diabetic foot ulcers with Wagner’s grades 1 and 2, no infection,
and adequate tissue blood flow were randomly assigned to one of three 81-person groups:
surgical debridement (the standard method), dehydrated amnion dressing, or platelet-derived
growth factor dressing. The follow-up period lasted 12 weeks. The percentage area
reduction (PAR) was measured as the final target. SPSS version 25 was used to perform
statistical analysis on the data.
Results
All three study groups were comparable in terms of the type of ulcer, the area of
ulcer, Wagner’s grade, the period, and the ulcer’s size. The PAR in the surgical debridement,
platelet-derived growth factor, and dehydrated amnion groups were 7.4%, 14.8%, and
49.3% in week 4; 20.1%, 35.8%, and 79% in week 6; 43.7%, 56.8%, 86.4% in week 8; and
50%, 61.7%, and 87.6% in weeks 10 and 12, respectively. The observed differences were
statistically significant (p < 0.05) over the entire period.
Conclusion
The study concluded that dehydrated amnion dressing, when compared to platelet-derived
growth factor dressing and surgical debridement, resulted in better-improved healing
in diabetic foot ulcer patients.
Keywords
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Article info
Publication history
Published online: February 08, 2022
Accepted:
February 4,
2022
Received in revised form:
January 6,
2022
Received:
September 14,
2021
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.
