Highlights
- •iPTH levels were significantly related to clinical outcomes in DKD patients.
- •Ectopic calcification was a risk for clinical outcomes in DKD patients.
- •DKD patients with higher iPTH levels had increased ectopic calcification rate.
- •DKD patients with higher iPTH levels had shorter survival time.
Abstract
Aim
We aimed to investigate the relationship between intact parathyroid hormone (iPTH)
levels and all-cause death, cardiovascular events, and ectopic calcification in patients
with diabetic kidney disease (DKD).
Methods
In this retrospective cohort study, we collected the clinical data of 508 patients
with clinically diagnosed DKD. The primary and secondary outcomes were all-cause death
or cardiovascular events and ectopic calcification, respectively. We used different
regression methods to analyze the relationship between various clinical parameters
and the two clinical outcomes.
Results
We found that iPTH was a risk factor for all-cause death and cardiovascular events
(hazards ration [HR]: 2.817, 95% confidence interval [CI]: 1.045–6.562, P = 0.016).
Meanwhile, diabetes duration (HR: 1.090, 95% CI: 1.045–1.138, P < 0.0001), triglycerides
(TG) (HR: 1.254, 95% CI: 1.049–1.499, P = 0.013), and iPTH (HR: 1.954, 95% CI: 1.001–3.813,
P = 0.049) were independent risk factors for ectopic calcification. In contrast to
patients with lower iPTH levels (iPTH < 31.7 pg/mL), patients with higher iPTH levels
(iPTH ≥ 31.7 pg/mL) had increased ectopic calcification rate (P = 0.002) and decreased
survival time (P < 0.001).
Conclusion
In patients with DKD, higher iPTH levels were significantly related to worsen clinical
outcomes.
Keywords
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Article info
Publication history
Published online: June 20, 2021
Accepted:
June 17,
2021
Received in revised form:
June 11,
2021
Received:
March 16,
2021
Identification
Copyright
© 2021 Published by Elsevier B.V.
