Advertisement
Research Article| Volume 172, 108644, February 2021

Effect of yoga intervention on biochemical, oxidative stress markers, inflammatory markers and sleep quality among subjects with type 2 diabetes in South India: Results from the SATYAM project

  • Vijay Viswanathan
    Correspondence
    Corresponding author at: No. 4, West Madha Church Street, Royapuram, Chennai 600 013, Tamil Nadu, India.
    Affiliations
    Department of Diabetology, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre (WHO Collaborating Centre for Research Education and Training in Diabetes) (IDF Centre for Excellence in Diabetes Care), Royapuram, Chennai, Tamil Nadu, India
    Search for articles by this author
  • Sumathi Sivakumar
    Affiliations
    Department of Yoga, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre (WHO Collaborating Centre for Research Education and Training in Diabetes) (IDF Centre for Excellence in Diabetes Care), Royapuram, Chennai, Tamil Nadu, India
    Search for articles by this author
  • A. Sai Prathiba
    Affiliations
    Department of Primary Prevention of Diabetes, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre (WHO Collaborating Centre for Research Education and Training in Diabetes) (IDF Centre for Excellence in Diabetes Care), Royapuram, Chennai, Tamil Nadu, India
    Search for articles by this author
  • Arutselvi Devarajan
    Affiliations
    Department of Epidemiology, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre (WHO Collaborating Centre for Research Education and Training in Diabetes) (IDF Centre for Excellence in Diabetes Care), Royapuram, Chennai, Tamil Nadu, India
    Search for articles by this author
  • Leema George
    Affiliations
    Department of Molecular Genetics, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre (WHO Collaborating Centre for Research Education and Training in Diabetes) (IDF Centre for Excellence in Diabetes Care), Royapuram, Chennai, Tamil Nadu, India
    Search for articles by this author
  • Satyavani Kumpatla
    Affiliations
    Department of Biochemistry, M.V. Hospital for Diabetes and Prof. M. Viswanathan Diabetes Research Centre (WHO Collaborating Centre for Research Education and Training in Diabetes) (IDF Centre for Excellence in Diabetes Care), Royapuram, Chennai, Tamil Nadu, India
    Search for articles by this author
Published:December 24, 2020DOI:https://doi.org/10.1016/j.diabres.2020.108644

      Abstract

      Aims

      The aim of this study was to investigate the effect of yoga intervention on the biochemical, oxidative stress markers and inflammatory markers and sleep quality among subjects with type 2 diabetes.

      Methods

      Subjects with type 2 diabetes attending a tertiary care centre for diabetes during Feb 2017 to Oct 2019 in Chennai, India were randomly assigned to two different groups. Group1(non-Yoga) (n = 150) was advised on simple physical exercises whereas group2(Yoga) (n = 150) was trained and advised to do yogasanas with static loosening exercises for 50 min for 5 days in a week. Both the groups were followed up for a period of 3 months. Anthropometric, biochemical, oxidative stress markers, inflammatory markers and sleep quality were assessed at baseline and after follow up.

      Results

      There was a significant reduction in BMI, blood glucose levels, HbA1c, lipid levels, IL6, TNFα and TBARS in Yoga group as compared to non-Yoga group. There was marked improvement in the levels of Adiponectin, PTGIS and sleep quality among subjects practising yogasanas.

      Conclusion

      Regular practice of yogasanas improved glycaemic control, oxidative stress, inflammatory response and sleep quality among subjects with type 2 diabetes. Hence, Yogasanas can be used as an adjuvant therapy for managing type 2 diabetes.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Diabetes Research and Clinical Practice
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

      1. International Diabetes Federation. IDF Diabetes Atlas,8th edn. Brussels, Belgium: International Diabetes Federation, 2019.

        • Kaveeshwar S.A.
        • Cornwall J.
        The current state of diabetes mellitus in India.
        Australas. Med. J. 2014; 7: 45-48https://doi.org/10.4066/AMJ.2014.1979
        • Freeman D.J.
        • Norrie J.
        • Caslake M.J.
        • Gaw A.
        • Ford I.
        • Lowe G.D.O.
        • et al.
        C-reactive protein is an independent predictor of risk for the development of diabetes in the west of Scotland coronary prevention study.
        Diabetes. 2002; 51: 1596-1600https://doi.org/10.2337/diabetes.51.5.1596
        • Li S.
        • Shin H.J.
        • Ding E.L.
        • van Dam R.M.
        Adiponectin levels and risk of type 2 diabetes.
        JAMA. 2009; 302: 179https://doi.org/10.1001/jama.2009.976
        • Paz-Filho G.
        • Mastronardi C.
        • Franco C.B.
        • Wang K.B.
        • Wong M.-L.
        • Licinio J.
        Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications.
        Arq Bras Endocrinol. Metabol. 2012; 56: 597-607https://doi.org/10.1590/s0004-27302012000900001
        • Brownlee M.
        The pathobiology of diabetic complications: a unifying mechanism.
        Diabetes. 2005; 54: 1615-1625https://doi.org/10.2337/diabetes.54.6.1615
        • Anjana R.M.
        • Pradeepa R.
        • Das A.K.
        • Deepa M.
        • Bhansali A.
        • Joshi S.R.
        • et al.
        Physical activity and inactivity patterns in India – results from the ICMR-INDIAB study (Phase I) (ICMR-INDIAB-5).
        Int. J. Behav. Nutr. Phys. Act. 2014; 11: 26
        • Malhotra V.
        • Singh S.
        • Tandon O.P.
        • Sharma S.B.
        The beneficial effect of yoga in diabetes.
        Nepal Med. Coll. J. 2005; 7: 145-149
        • Kumpatla S.
        • Michael C.
        • Viswanathan V.
        Effect of yogasanas on glycaemic, haemodynamic and lipid profile in newly diagnosed subjects with type 2 diabetes.
        Int. J. Diabetes Dev. Countries. 2015; 35: 181-188https://doi.org/10.1007/s13410-014-0255-2
        • Maninder B.
        • Seema D.
        • Shema N.
        Influence of pranayamas and yoga-asanas on blood glucose, lipid profile and hba1c in type 2 diabetes.
        Int. J. Pharma Bio Sci. 2013; 4: 2020
        • Kiecolt-Glaser J.K.
        • Christian L.
        • Preston H.
        • Houts C.R.
        • Malarkey W.B.
        • Emery C.F.
        • et al.
        Stress, inflammation and Yoga practice.
        Psychosom Med. 2010; 72: 113https://doi.org/10.1097/PSY.0b013e3181cb9377
        • Alotaibi A.D.
        • Alosaimi F.M.
        • Alajlan A.A.
        • Bin Abdulrahman K.A.
        The relationship between sleep quality, stress and academic performance among medical students.
        J. Family Community Med. 2020; 27: 23-28
        • Prather A.A.
        • Puterman E.
        • Epel E.S.
        • Dhabhar F.S.
        Poor sleep quality potentiates stress-induced cytokine reactivity in postmenopausal women with high visceral abdominal adiposity.
        Brain Behav. Immun. 2014; 35: 155-162https://doi.org/10.1016/j.bbi.2013.09.010
        • Hegde S.V.
        • Adhikari P.
        • Kotian S.
        • Pinto V.J.
        • D’Souza S.
        • D’Souza V.
        Effect of 3-month yoga on oxidative stress in type 2 diabetes with or without complications: a controlled clinical trial.
        Diabetes Care. 2011; 34: 2208-2210https://doi.org/10.2337/dc10-2430
        • Singh S.
        • Malhotra V.
        • Singh K.P.
        • Sharma S.B.
        • Madhu S.V.
        • Tandon O.P.
        A preliminary report on the role of yoga asanas on oxidative stress in non-insulin dependent diabetes mellitus.
        Indian J. Clin. Biochem. 2001; 16: 216-220
        • Khalsa S.B.S.
        Treatment of chronic insomnia with yoga: a preliminary study with sleep-wake diaries.
        Appl. Psychophysiol. Biofeedback. 2004; 29: 269-278https://doi.org/10.1007/s10484-004-0387-0
        • Buysse D.J.
        • Reynolds C.F.
        • Monk T.H.
        • Berman S.R.
        • Kupfer D.J.
        PSQI - EscalaAvaliaçãoSono.
        Psychiatry Res. 1989; 28: 193-213
        • Tug T.
        • Karatas F.
        • Terzi S.M.
        • Ozdemir N.
        Comparison of serum malondialdehyde levels determined by two different methods in patients with COPD: HPLC or TBARS methods.
        Lab. Med. 2005; 36: 41-44https://doi.org/10.1309/WTEET9TJ2LUMB3C3
        • Viswanathan V.
        • Chacko P.T.
        • Lavanya M.
        • Tilak P.
        A proof of concept, preliminary study to determine the effect of Yogasnas in controlling type 2 diabetes mellitus in newly detected subjects (when compared to metformin monotherapy) [5].
        J. Assoc. Physicians India. 2006; 54: 965-966
        • Elder C.
        • Aickin M.
        • Bauer V.
        • Cairns J.
        • Vuckovic N.
        Randomized trial of a whole-system ayurvedic protocol for type 2 diabetes.
        Altern. Ther. Health Med. 2006; 12: 24-30
        • Skoro-Kondza L.
        • Tai S.S.
        • Gadelrab R.
        • Drincevic D.
        • Greenhalgh T.
        Community based yoga classes for type 2 diabetes: an exploratory randomised controlled trial.
        BMC Health Serv. Res. 2009; 9: 1-8https://doi.org/10.1186/1472-6963-9-33
        • Bindra M.
        • Nair
        • Darotiya S.
        Influence of pranayamas and yogaasanas on blood glucose, lipid profile and HbA1c in type 2 diabetes.
        Int. J. Pharm. Biol. Sci. 2013; 4: 169-172
        • Jyotsna V.
        • Ambekar S.
        • Dhawan A.
        • Joshi A.
        • Kumar N.
        • Sreenivas V.
        Comprehensive yogic breathing program improves quality of life in patients with diabetes.
        Indian J. Endocrinol. Metab. 2012; 16: 423https://doi.org/10.4103/2230-8210.95692
        • Shantakumari N.
        • Sequeira S.
        • El Deeb R.
        Effects of a yoga intervention on lipid profiles of diabetes patients with dyslipidemia.
        Indian Heart J. 2013; 65: 127-131https://doi.org/10.1016/j.ihj.2013.02.010
        • Gupta M.
        • Chari S.
        Proxidant and antioxidant status in patients of type II diabetes mellitus with IHD.
        Indian J. Clin. Biochem. 2006; 21: 118-122https://doi.org/10.1007/BF02912925
        • Sriakshmi V.H.
        • Prabha A.
        • Sashidhar K.
        • Rajeshwari S.
        • Kalpana A.
        Effect of yoga on oxidative stress in elderly type 2 diabetes subjects.
        J. Yoga Phys. Ther. 2016; 06: 2-6https://doi.org/10.4172/2157-7595.1000258
        • Raison C.L.
        • Capuron L.
        • Miller A.H.
        Cytokines sing the blues: Inflammation and the pathogenesis of depression.
        Trends Immunol. 2006; 27: 24-31https://doi.org/10.1016/j.it.2005.11.006
        • Shete S.U.
        • Verma A.
        • Kulkarni D.D.
        • Bhogal R.S.
        Effect of yoga training on inflammatory cytokines and C-reactive protein in employees of small-scale industries.
        J. Educ. Health Promot. 2017; 6: 76https://doi.org/10.4103/jehp.jehp_65_17.Corpus ID: 24242670
        • Singh V.K.
        • Bhandari R.B.
        • Rana B.B.
        Effect of yogic package on rheumatoid arthritis.
        Indian J. Physiol. Pharmacol. 2011; 55: 329-335
        • Yadav R.K.
        • Magan D.
        • Mehta N.
        • Sharma R.
        • Mahapatra S.C.
        Efficacy of a short-term yoga-based lifestyle intervention in reducing stress and inflammation: preliminary results.
        J. Altern. Complementary. Med. 2012; 18: 662-667https://doi.org/10.1089/acm.2011.0265
        • Wolff M.
        • Memon A.A.
        • Chalmers J.P.
        • Sundquist K.
        • Midlöv P.
        Yoga’s effect on inflammatory biomarkers and metabolic risk factors in a high risk population - a controlled trial in primary care.
        BMC Cardiovasc. Disord. 2015; 15: 1-7https://doi.org/10.1186/s12872-015-0086-1
        • Sarvottam K.
        • Magan D.
        • Yadav R.K.
        • Mehta N.
        • Mahapatra S.C.
        Adiponectin, interleukin-6, and cardiovascular disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men.
        J. Altern. Complementary Med. 2013; 19: 397-402https://doi.org/10.1089/acm.2012.0086
        • Knuston K.L.
        • Cauter E.V.
        Association between sleep loss and increased risk of obesity and diabetes.
        Ann. N. Y Acad. Sci. 2008; 1129: 287-304https://doi.org/10.1196/annals.1417.033
        • Manjunath N.K.
        • Telles S.
        Influence of Yoga & Ayurveda on self-rated sleep in a geriatric population.
        Indian J. Med. Res. 2005; 121: 683-690
        • Rshikesan P.B.
        • Subramanya P.
        • Singh D.
        Sleep quality and body composition variations in obese male adults after 14 weeks of yoga intervention: a randomized controlled trial.
        Int. J. Yoga. 2017; 10: 128-137https://doi.org/10.4103/ijoy.IJOY_53_16
        • Hariprasad V.R.
        • Sivakumar P.T.
        • Koparde V.
        • Varambally S.
        • Thirthalli J.
        • Varghese M.
        • et al.
        Effects of yoga intervention on sleep and quality-of-life in elderly: a randomized controlled trial.
        Indian J. Psychiatry. 2013; 55https://doi.org/10.4103/0019-5545.116310
        • Ebrahimi M.
        • Guilan-Nejad T.N.
        • Pordanjani A.F.
        Effect of yoga and aerobics exercise on sleep quality in women with Type 2 diabetes: a randomized controlled trial.
        Sleep Sci. 2017; 10: 68-72https://doi.org/10.5935/1984-0063.20170012