Highlights
- •Spexin is a neuropeptide, with regulatory role in obesity and its co-morbiditie.
- •Spexin appears to have a positive impact on overall metabolic status in adolescents.
- •spexin, may have a positive impact on adipose tissue and adipose tissue metabolism.
Abstract
Aims
The aim of the present study was to investigate whether circulating levels of spexin
is related to metabolic syndrome, some dietary intakes (Total energy intake, Macronutrient intakes) and body composition in children.
Methods
90 children were recruited in the present cross sectional study. Anthropometric measures,
body composition, blood pressure, dietary intakes, resting metabolic rate, physical
activity level, appetite status, pubertal stage, serum spexin, fasting blood glucose,
high-sensitivity C-reactive protein, insulin and lipid profile were measured using
standard techniques.
Results
14 children met the criteria for metabolic syndrome. Median (IQR) of spexin levels
were significantly lower in children with high fat mass and children with higher systolic
blood pressure (SBP), compared to children with normal fat mass and normal SBP: (P < 0.05).
A protective independent effect was detected for the highest tertile of serum spexin
on metabolic syndrome in adjusted models; Crude OR (CI): 0.23 (0.04–1.2), P-trend = 0.08;
Model 1: OR (CI): 0.15(0.02–1.01), P-trend = 0.05; Model 2: OR (CI): 0.10 (0.01–0.90),
P-trend = 0.03. There was a significant negative association between spexin and total
dietary fat intake (r= − 0.21; P < 0.04).
Conclusion
This findings can further highlight the importance of the relationship between spexin,
adipose tissue and adipose tissue metabolism.
Keywords
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Article info
Publication history
Published online: December 18, 2020
Accepted:
December 15,
2020
Received in revised form:
November 23,
2020
Received:
April 12,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
