Highlights
- •This is the first report on the chronic effects of suvorexant in type 2 diabetes patients.
- •Suvorexant improved sleep quality, abdominal circumference, and sucrose intake.
- •Magnitude of sleep quality changes was associated with that in HbA1c and BW.
Abstract
Aims
This study aimed to assess the chronotherapeutic efficacy of suvorexant on subjective
sleep parameters and metabolic parameters in patients with type 2 diabetes and insomnia.
Methods
Thirteen patients with type 2 diabetes who met the Pittsburg Sleep Quality index criteria
for primary insomnia took suvorexant 20 mg/day (15 mg/day for ≥65 years) for 14 ± 2 weeks.
The following parameters were assessed before and after the treatment: sleep diary
for sleep duration and quality (i.e., sleep onset latency, waking after sleep onset,
and sleep efficiency [sSE]), Insomnia Severity Index, clinical and biochemical data,
continuous glucose monitoring (CGM), and validated self-administered questionnaire
on food intake.
Results
Suvorexant significantly improved sSE, abdominal circumference, and sucrose intake
(all p < 0.05), but did not change HbA1c, CGM parameters, or body weight. Correlation
analysis revealed that changes in sSE were associated with those in HbA1c and body
weight (r = −0.61 and r = −0.66, respectively; both p < 0.05).
Conclusions
Suvorexant significantly improved sleep quality and obesity-associated parameters
in patients with type 2 diabetes in 14 weeks. Improvements in sleep quality were associated
with improvements in glycemic control. Sleep disorder treatment using suvorexant may
provide metabolic benefits for patients with type 2 diabetes.
Keywords
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Article info
Publication history
Published online: September 07, 2020
Accepted:
August 28,
2020
Received in revised form:
August 6,
2020
Received:
March 18,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
