Abstract
Aim
An analysis is made of the saliva and plasma levels of trace elements in patients
with type 2 diabetes mellitus and their association to metabolic control and the presence
of chronic complications.
Methods
A cross-sectional observational clinical study was carried out in 74 patients with
type 2 diabetes mellitus. Mass spectrometry (ICP-MS) was used to determine the following
trace elements in plasma and unstimulated basal saliva: 13Al, 16S, 4Be, 5B, 20Ca, 27Co, 29Cu, 24Cr, 38Sr, 15P, 3Li, 12Mg, 25Mn, 28Ni, 82Pb, 37Rb, 22Ti, 23V and 30Zn.
Results
The levels of cobalt (p = 0.048) in saliva and of strontium (p = 0.001) in plasma
were related to the presence of chronic complications. Significant differences with
respect to metabolic control were observed for beryllium (p = 0.038), boron (p = 0.023)
and phosphorus in saliva (p = 0.046), and for rubidium (p = 0.005), titanium (p = 0.016)
and zinc in plasma (p = 0.013). A significant correlation (p < 0.001) was found between
boron in plasma and boron in unstimulated basal saliva.
Conclusions
The determination of trace elements in plasma and saliva constitutes a complementary
tool for the assessment of metabolic control and for predicting chronic complications
associated to type 2 diabetes mellitus. Further studies involving the biomonitoring
of trace elements in saliva and plasma are needed.
Keywords
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Article info
Publication history
Published online: October 08, 2019
Accepted:
September 25,
2019
Received in revised form:
August 17,
2019
Received:
July 26,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
