Abstract
Aims
To assess the risk of macrovascular complications in patients developing diabetes
from statin treatment.
Methods
In this population-based cohort study, 40,409 participants who began to receive statin
therapy between 2000 and 2012 were enrolled in to the study group, and another 1:1
matched adults without statin treatment during the same period served as the control
group. Both groups were followed up to identify individuals who later developed diabetes.
After a follow-up identification of diabetes, diabetes and non-diabetes cohorts were
subjected to an analysis for the risk of macrovascular events between diagnosis of
diabetes and December 31, 2013.
Results
Compared with individuals without statin therapy, statin-treated patients had a higher
risk of developing diabetes (adjusted hazard ratio: 2.46; 95% confidence interval:
2.37–2.57). Compared with statin-treated patients without diabetes, statin-treated
participants developing diabetes had a higher overall incidence of macrovascular complications
(adjusted hazard ratio: 1.74; 95% confidence interval: 1.62–1.88). Moreover, compared
with that of other diabetogenic statins, patients taking pravastatin had a lower risk
of developing diabetes (adjusted hazard ratio: 0.63; 95% confidence interval: 0.55–0.73)
and macrovascular events (adjusted hazard ratio: 0.64; 95% confidence interval: 0.42–0.98).
Conclusions
According to these findings, prescribing statins that have a neutral effect on glucose
homeostasis may be advisable for Asian populations.
Keywords
Abbreviations:
CV (cardiovascular), NHI (Taiwan national health insurance), NHIRD (the Taiwan national health insurance research database), LHID (the longitudinal health insurance database), ACS (acute coronary syndrome), MI (myocardial infarction), PDC (proportion of follow-up days on statin use), HTN (hypertension), CHF (congestive heart failure), CKD (chronic renal disease), WOSCOPS (the West of Scotland coronary prevention study), JUPITER (justification for the use of statins in prevention: an intervention trial evaluating rosuvastatin)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: September 24, 2019
Accepted:
September 23,
2019
Received in revised form:
September 11,
2019
Received:
July 25,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
