Highlights
- •HTN may accelerate cortical thickness reduction in T2DM patients.
- •T2DM showed cognitive dysfunction and elevated CRP level.
- •HTN, Insulin resistance and blood lipid are associated with CT alterations in T2DM patients.
Abstract
Aims
Although hypertension (HTN) is the high comorbidity of Type 2 diabetes mellitus (T2DM)
and known to be a vascular risk factor for brain damage, the effects of HTN on brain
function in T2DM patients are not well understood. Present study was performed to
investigate whether HTN might accelerate the Cerebral cortical thickness (CT) alterations
in patients with T2DM.
Methods
We enrolled 35 participants with only T2DM, 25 T2DM patients with HTN (HT2DM) and
28 healthy controls (HCs). The cognitive function was assessed and brain image data
was collected then the CT was calculated for each participant. Partial correlations
between the CT of each brain region and standard laboratory testing data and neuropsychological
scale scores were also analyzed. Multivariable regression analysis was performed to
evaluated the vascular risk factors and brain regions with different CT in HT2DM patients.
Results
Cognitive impairment is associated with thinning of the cerebral cortical thickness
reduction in T2DM patients. CT thinning in the left inferior parietal lobe, left posterior
cingulate and right precuneus were observed in HT2DM group relative to only T2DM group.
Furthermore, the CT decreasing in the right precuneus was negatively correlated with
duration of HTN.
Conclusion
The current study revealed that coexistent HTN may accelerate the CT reduction in
T2DM patients.
Keywords
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Article info
Publication history
Published online: October 05, 2019
Accepted:
September 30,
2019
Received in revised form:
August 31,
2019
Received:
July 30,
2019
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
