Abstract
The relationship between glycaemia, arrhythmia and changes in electrocardiogram (ECG)
has been addressed showing mixed results. The objective of this study was to evaluate
the changes in ECG, evaluated by Holter monitoring, induced by clinical hypoglycaemia
in patients with type 1 diabetes (T1DM) and type 2 diabetes (T2DM), aged 50 or older,
with high cardiovascular risk. Five-lead Holter monitoring (BL-900 Braemar, Inc, Norav
Medical NH301-2.4.5 software), and blinded interstitial continuous glucose monitoring
(CGM) (Dexcom G4-Platinum, range 40–400 mg/dl) was performed with time synchronization.
In the Holter registry, in patients with hypoglycemic episodes, mean QTc during hypoglycaemia
was longer compared to mean QTc in total group (+4.6 ms, p = 0.037) and T1DM patients
(+5.5 ms, p = 0.048) but not in T2DM patients (+3 ms, p = 0.459). During hypoglycaemia,
non-clinical significant disturbances in heart rhythm were observed.
In conclusion, we observed a prolongation in QTc during hypoglycemia, mainly in T1DM.
However, our study does not show a relationship between episodes of hypoglycaemia
and clinical arrhythmias, at least in T1DM and T2DM patients with high cardiovascular
risk.
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References
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Article info
Publication history
Published online: February 04, 2018
Accepted:
January 23,
2018
Received in revised form:
December 14,
2017
Received:
November 21,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
