Abstract
Aim
Dozens of susceptibility loci have been identified by type 2 diabetes (T2D) genome
wide association study (GWAS) in Europeans. In our previous studies, we systematically
evaluated the association of 48 susceptibility loci with T2D risk in Chinese Hans.
Because dyslipidemia and hyperglycemia are implicated in the pathogenic process of
T2D, we further evaluated whether these 48 single nucleotide polymorphisms (SNPs)
were related to fasting plasma glucose (FPG) or lipid levels in Chinese Hans.
Methods
The 48 SNPs were genotyped by using the Taqman OpenArray Genotyping System and iPLEX
Sequenom MassARRAY platform. Multiple linear regression was used to assess the relationship
between genetic variants and FPG and lipid levels among 3281 non-diabetic, healthy
Chinese Hans.
Results
After adjusting for age, gender, body mass index (BMI), smoking status and drinking
status, the T allele of rs13266634 in the SLC30A8 gene was significantly associated with decreased glucose level (β = −0.0119, P = 8.05 × 10−5), whereas the T allele of rs896854 in the TP53INP1 gene was associated with increased triglyceride (TG) level (β = 0.0342, P = 9.61 × 10−4) and decreased high-density lipoprotein cholesterol (HDL-C) level (β = −0.015, P = 3.24 × 10−3) after Bonferroni correction. We also conducted a meta-analysis consisted of 11 studies
and confirmed that SNP rs896854 in the TP53INP1 gene was associated with T2D risk.
Conclusion
Our findings indicated that SNP rs13266634 in SLC30A8 was associated with glucose level and SNP rs896854 in TP53INP1 was associated with lipid level.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Diabetes Research and Clinical PracticeAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.Diabetes. 2009; 58: 773-795
The International Diabetes Federation. <http://www.diabetesatlas.org/>.
- Prevalence and control of diabetes in Chinese adults.JAMA. 2013; 310: 948-959
- Type 2 diabetes: principles of pathogenesis and therapy.Lancet. 2005; 365: 1333-1346
- Triglycerides and HDL cholesterol: stars or second leads in diabetes?.Diabetes Care. 2009; 32: S373-S377
- Normal fasting plasma glucose levels and type 2 diabetes in young men.N Engl J Med. 2005; 353: 1454-1462
- Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults.N Engl J Med. 2010; 362: 800-811
- HbA1c 5.7–6.4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): a longitudinal cohort study.Lancet. 2011; 378: 147-155
- Prediction of incident diabetes mellitus in middle-aged adults: the Framingham Offspring Study.Arch Int Med. 2007; 167: 1068-1074
- Cumulative effect and predictive value of genetic variants associated with type 2 diabetes in Han Chinese: a case-control study.PLoS ONE. 2015; 10: e0116537
- The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population.J Hum Genet. 2010; 55: 600-604
- The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes.Diabetologia. 2008; 51: 70-75
- Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.Diabetes. 2015; 64: 291-298
- Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese.J Hum Genet. 2012; 57: 320-325
- Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.PLoS ONE. 2012; 7: e35060
- Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.Nat Genet. 2010; 42: 579-589
- Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese.PLoS ONE. 2011; 6: e26911
- Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations.Diabetologia. 2011; 54: 1368-1374
- European genetic variants associated with type 2 diabetes in North African Arabs.Diabetes Metab. 2012; 38: 316-323
- Joint effect of genetic and lifestyle risk factors on type 2 diabetes risk among Chinese men and women.PLoS ONE. 2012; 7: e49464
- Assessing the contribution of 38 genetic loci to the risk of type 2 diabetes in the Saudi Arabian population.Clin Endocrinol. 2014; 80: 532-537
- Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.Diabetes. 2013; 62: 977-986
- A comparison of type 2 diabetes risk allele load between African Americans and European Americans.Hum Genet. 2014; 133: 1487-1495
- Role of established Type 2 diabetes-susceptibility genetic variants in a high prevalence American Indian population.Diabetes. 2015; 64: 2646-2657
- Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank.Diabetologia. 2016; 59: 1446-1457
- Association of SLC30A8 gene polymorphism with type 2 diabetes, evidence from 46 studies: a meta-analysis.Endocrine. 2016; 53: 381-394
- Replication of genome-wide association study (GWAS) loci for fasting plasma glucose in African-Americans.Diabetologia. 2011; 54: 783-788
- Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.Diabetes. 2015; 64: 291-298
- Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.PLoS Genet. 2008; 4: e1000312
- A genome wide association study identifies common variants associated with lipid levels in the Chinese population.PLoS ONE. 2013; 8: e82420
- Association analyses of Eastern Asian individuals and trans-ancestry analyses with European individual reveal new loci associated with cholesterol and triglyceride levels.Hum Mol Genet. 2017; 26: 1770-1784
- Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1.EMBO Mol Med. 2015; 7: 802-818
Article info
Publication history
Published online: March 05, 2018
Accepted:
February 27,
2018
Received in revised form:
February 2,
2018
Received:
October 19,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
