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Population-based cohort study suggesting a significantly increased risk of developing chronic obstructive pulmonary disease in people with type 2 diabetes mellitus

  • I-Lin Hsu
    Affiliations
    Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Department of Emergency Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • Chin-Li Lu
    Affiliations
    Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • Chia-Chun Li
    Affiliations
    Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • Sheng-Han Tsai
    Affiliations
    Division of Chest Medicine, Department of Internal Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
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  • Chiung-Zuei Chen
    Affiliations
    Division of Chest Medicine, Department of Internal Medicine, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
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  • Susan C. Hu
    Affiliations
    Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
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  • Chung-Yi Li
    Correspondence
    Corresponding author at: Department and Graduate Institute of Public Health, College of Medicine, National Cheng Kung University, #1, University Rd., Tainan 701, Taiwan.
    Affiliations
    Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan
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Published:February 03, 2018DOI:https://doi.org/10.1016/j.diabres.2018.01.037

      Abstract

      Aims

      To investigate whether type 2 diabetes mellitus (T2DM) increases the risk of developing chronic obstructive pulmonary disease (COPD).

      Methods

      This population-based cohort study used Taiwan’s National Health insurance claim data to investigate the association of T2DM with the risk of COPD. A total of 716,623 pairs of people (patients with T2DM and their age-, sex-, and calendar year-matched controls) were identified in 2002–2003 and were followed until the occurrence of newly-diagnosed COPD or the end of 2011. Cox proportional hazard models were used to relate COPD incidence to T2DM.

      Results

      People with T2DM experienced a higher incidence rate of COPD than controls (159.6 vs 122.7 per 104 person-years). After controlling for confounders, T2DM significantly increased the hazard of COPD (hazard ratio [HR] = 1.15, 95% confidence interval = 1.14–1.16). Stratified analysis indicated that the association between T2DM and COPD was slightly greater in women than in men (HR, 1.15 vs. 1.11) and in people aged <65 years than in people aged ≥65 years (HR, 1.17 vs. 1.05 in men; 1.16 vs. 1.13 in women).

      Conclusions

      Our findings demonstrated a modest association of T2DM with the risk of developing COPD, possibly shedding light into the adverse effects of hyperglycemia on pulmonary function.

      Keywords

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