Highlights
- •The risk of developing impaired insulin secretion increases with increase in alcohol consumption.
- •The risk of developing insulin resistance increases with increase in alcohol consumption.
- •There is no sex difference in the associations between alcohol consumption and the risk of insulin action.
Abstract
Aims
To investigate the effect of alcohol consumption on impaired insulin secretion and
insulin resistance in Japanese.
Methods
The participants in this 5-year cohort study were 2100 Japanese aged 30–74 years without
type 2 diabetes mellitus, impaired insulin secretion, or insulin resistance who underwent
a medical checkup including 75-g OGTT between April 2008 and March 2009 at Saku Central
Hospital. Alcohol consumption was categorized as follows: non-drinker (0 g/week),
light drinker (1–139 g/week in men and 1–69 g/week in women), moderate drinker (140–274 g/week
in men and 70–139 g/week in women) and heavy drinker (≥275 g/week in men and ≥140 g/week
in women). The hazard ratios (HRs) and 95% CIs among light to heavy drinkers for incidence
of impaired insulin secretion (insulinogenic index ≤51.7) and insulin resistance (HOMA-IR ≥ 2.5),
detected by an OGTT at the time of a follow-up medical checkup before the end of March
2014, were estimated by multivariable adjusted Cox proportional hazard models as reference
values for non-drinkers.
Results
There were 708 cases of impaired insulin secretion and 191 cases of insulin resistance.
The HRs (95% CIs) for impaired insulin secretion in light, moderate and heavy drinkers
were 1.16 (0.96–1.40), 1.35 (1.07–1.70) and 1.64 (1.24–2.16), respectively (P for
trend <0.001). For insulin resistance, the HRs were 1.22 (0.84–1.76), 1.42 (0.91–2.22)
and 1.59 (0.96–2.65), respectively (P for trend = 0.044).
Conclusion
Alcohol consumption was positively associated with the incidence of both impaired
insulin secretion and insulin resistance.
Keywords
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Article info
Publication history
Published online: October 27, 2017
Accepted:
October 24,
2017
Received in revised form:
October 5,
2017
Received:
July 31,
2017
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
