Highlights
- •Increased plasma triglyceride was associated with a higher risk of CKD among the Thai diabetic population.
- •Study findings suggest to incorporate triglyceride monitoring in routine clinical practices.
- •High TG level could guide physicians to institute early preventive measures to slow CKD progression.
Abstract
Aims
To investigate the observational association between plasma triglyceride and CKD in
patients with T2DM.
Methods
A hospital-based retrospective registry was used to obtain data of 3,748 T2DM patients
from May 2016 to October 2016. Anthropometric measurements and biochemical reports
of T2DM patients with CKD were obtained by data extraction of medical records. CKD
was defined according to the estimated glomerular filtration rate (eGFR< 60 mL/min/1.73 m2). Multiple logistic regression was used to determine the association between plasma
triglyceride and CKD.
Results
The mean age of the participants was 61.4 ± 11.0 years, and a majority of them was
female (64%) with poor glycemic control (83%), increased plasma triglyceride (51%)
and 27% of T2DM patients had CKD. There was a significant trend towards deteriorating
renal function (lower eGFR) with categorically raised triglyceride levels. After controlling
for age, sex and other confounders, ‘borderline high’ (adjusted odds ratio (OR): 1.24,
95% confidence interval (CI): 1.01–1.54), ‘high’ (adjusted OR: 1.52, 95% CI: 1.24–1.85)
and ‘very high’ (adjusted OR: 3.40, 95% CI: 1.94–5.94) triglyceride level groups had
higher likelihood to have CKD compared to normal triglyceride level.
Conclusion
CKD was associated with a higher level of plasma triglyceride among patients with
T2DM. These results support the rationale to screen and manage increased triglyceride
in routine clinical practices among persons with diabetes to prevent CKD.
Abbreviations:
CKD (Chronic kidney disease), TG (Triglyceride), AOR (Adjusted odds ratio), COR (Crude odds ratio), MDRD-4 (Modification of diet in renal disease 4 variables), HbA1c (Glycated haemoglobin), LDL-C (Low density lipoprotein cholesterol), WHO (World Health Organization), NKF-KDOQI (National Kidney Disease Outcomes Quality Initiative), eGFR (estimated Glomerular Filtration Rate)Keywords
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Article info
Publication history
Published online: February 12, 2018
Accepted:
February 6,
2018
Received in revised form:
December 25,
2017
Received:
June 22,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
