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Plasma triglycerides as a risk factor for chronic kidney disease in type 2 diabetes mellitus: Evidence from northeastern Thailand

Published:February 12, 2018DOI:https://doi.org/10.1016/j.diabres.2018.02.011

      Highlights

      • Increased plasma triglyceride was associated with a higher risk of CKD among the Thai diabetic population.
      • Study findings suggest to incorporate triglyceride monitoring in routine clinical practices.
      • High TG level could guide physicians to institute early preventive measures to slow CKD progression.

      Abstract

      Aims

      To investigate the observational association between plasma triglyceride and CKD in patients with T2DM.

      Methods

      A hospital-based retrospective registry was used to obtain data of 3,748 T2DM patients from May 2016 to October 2016. Anthropometric measurements and biochemical reports of T2DM patients with CKD were obtained by data extraction of medical records. CKD was defined according to the estimated glomerular filtration rate (eGFR< 60 mL/min/1.73 m2). Multiple logistic regression was used to determine the association between plasma triglyceride and CKD.

      Results

      The mean age of the participants was 61.4 ± 11.0 years, and a majority of them was female (64%) with poor glycemic control (83%), increased plasma triglyceride (51%) and 27% of T2DM patients had CKD. There was a significant trend towards deteriorating renal function (lower eGFR) with categorically raised triglyceride levels. After controlling for age, sex and other confounders, ‘borderline high’ (adjusted odds ratio (OR): 1.24, 95% confidence interval (CI): 1.01–1.54), ‘high’ (adjusted OR: 1.52, 95% CI: 1.24–1.85) and ‘very high’ (adjusted OR: 3.40, 95% CI: 1.94–5.94) triglyceride level groups had higher likelihood to have CKD compared to normal triglyceride level.

      Conclusion

      CKD was associated with a higher level of plasma triglyceride among patients with T2DM. These results support the rationale to screen and manage increased triglyceride in routine clinical practices among persons with diabetes to prevent CKD.

      Abbreviations:

      CKD (Chronic kidney disease), TG (Triglyceride), AOR (Adjusted odds ratio), COR (Crude odds ratio), MDRD-4 (Modification of diet in renal disease 4 variables), HbA1c (Glycated haemoglobin), LDL-C (Low density lipoprotein cholesterol), WHO (World Health Organization), NKF-KDOQI (National Kidney Disease Outcomes Quality Initiative), eGFR (estimated Glomerular Filtration Rate)

      Keywords

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