Highlights
- •Synbiotic supplementation significantly reduced SBP and DBP.
- •Synbiotic led to significant within group increases in HDL-C and TAC levels in synbiotic group.
- •Serum levels of TC and TG were significantly increases in both groups.
- •A significant within group increase was found in LDL-C levels in placebo group.
- •Short term supplementation of synbiotic may be useful in management of gestational diabetes mellitus complications.
Abstract
Aims
The role of gut microbiota in the management of diabetes is shown. In this randomized
clinical trial we assessed the effects of synbiotic supplementation on insulin, lipid
profile and antioxidative status among women with gestational diabetes mellitus (GDM).
Methods
Ninety pregnant women with GDM were randomly assigned into two groups to receive either
a daily synbiotic capsule – consisting of L. acidophilus, L. plantarum, L. fermentum, L. gasseri (1.5–7.0 × 109–10 CFU/g) – with fructooligosaccharide (38.5 mg), or placebo for 6 weeks. Fasting plasma
glucose (FPG), insulin, homeostasis model assessment-insulin resistance (HOMA-IR),
quantitative insulin sensitivity check index (QUICKI), high- and low density lipoprotein
cholesterol (HDL-C, LDL-C), total cholesterol (TC), triglycerides (TG), total antioxidant
capacity (TAC), and systolic and diastolic blood pressure (SBP, DSP) were assessed
before and after the intervention.
Results
No significant changes in FPG, insulin resistance/sensitivity, lipid profile and TAC
indices were seen in synbiotic group compared to the placebo one (p > 0.05). Significant
within group increases for HDL-C and TAC levels in synbiotic group were observed (p < 0.05).
LDL-C showed significant increment in the placebo group compared to the baseline of
the study (6.9 mg/dL, p < 0.05). Between group comparison showed significant decrease
in SBP and DBP in synbiotic group compared to placebo (−2.5 vs. 8.6 mmHg, and −1.8
vs. 2.1 mmHg, p < 0.05).
Conclusions
The results showed that, in women with GDM, synbiotic supplementation had no effect
on FPG and insulin resistance/sensitivity indices. Lipid profile and TAC status may
be affected by synbiotic supplementation. Synbiotic is effective in reducing of blood
pressure in women with GDM.
Keywords
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Article info
Publication history
Published online: February 09, 2018
Accepted:
February 5,
2018
Received in revised form:
November 6,
2017
Received:
June 26,
2017
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
