Highlights
- •Offspring birth weight related to maternal anthropometry and metabolism postpartum.
- •Drivers may be maternal insulin resistance, lipid metabolism and lifestyle factors.
Abstract
Aims
We aimed to assess whether female offspring birth weight (BW) is associated with anthropometric
and metabolic outcomes in Chilean mothers at 10-years postpartum.
Methods
We assessed data from 396 Chilean mother-daughter pairs participating in the longitudinal
Chilean Growth and Obesity Cohort (GOCS) and Determinants of Breast Cancer Risk (DERCAM)
studies. Multivariate linear and logistic regression models were performed to associate
female offspring BW with maternal Body Mass Index (BMI), waist circumference, type
2 diabetes mellitus, metabolic syndrome and its components at 10-years postpartum.
Results
At 10-years postpartum, 69% of mothers were overweight, 65% had central adiposity
and 26% had metabolic syndrome. Adjusted linear regression models showed associations
between female offspring BW and (1) maternal BMI (%Δ GM = 4.46; 95% CI 0.25–8.85);
and (2) waist circumference (%Δ GM = 3.25; 95% CI 0–6.60). Adjusted logistic regression
models showed associations between female offspring BW and (1) maternal metabolic
syndrome (OR = 3.48; 95% CI 1.50–8.11); (2) central adiposity (OR = 2.37; 95% CI 1.08–5.22);
and (3) hypertriglyceridemia (OR = 3.19; 95% CI 1.40–7.23).
Conclusions
Female offspring BW was associated with maternal anthropometric and metabolic outcomes
at 10-years postpartum. Our findings add to the emerging evidence that offspring BW
might be a potential indicator for future maternal anthropometric and metabolic risks.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Diabetes Research and Clinical PracticeAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- The fetal insulin hypothesis: an alternative explanation of the association of low birth weight with diabetes and vascular disease.Lancet. 1999; 353: 1789-1792
- Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals.Environ Health Prev Med. 2013; 18: 185-197https://doi.org/10.1007/s12199-013-0328-8
- Maternal smoking during pregnancy and daughters’ risk of gestational diabetes and obesity.Diabetologia. 2014; 56: 1689-1695https://doi.org/10.1007/s00125-013-2936-7
- Prenatal Concentrations of Polychlorinated Biphenyls, DDE, and DDT and Overweight in Children: A Prospective Birth Cohort Study.Environ Health Perspect. 2012; 120: 451-457https://doi.org/10.1289/ehp.1103862
- Biological embedding of early-life exposures and disease risk in humans: a role for DNA methylation.Eur J Clin Invest. 2015; 45: 303-332https://doi.org/10.1111/eci.12406
- Epigenomics, gestational programming and risk of metabolic syndrome.Int J Obes. 2015; 39: 633-641https://doi.org/10.1038/ijo.2015.13
- Parental determinants of neonatal body composition.J Clin Endocrinol Metab. 2007; 92: 523-526https://doi.org/10.1210/jc.2006-0456
- Estimating the relative contributions of maternal genetic, paternal genetic and intrauterine factors to offspring birth weight and head circumference.Early Hum Dev. 2010; 86: 425-432https://doi.org/10.1016/j.earlhumdev.2010.05.021
- Maternal Weight and Body Composition during Pregnancy Are Associated with Placental and Birth Weight in Rural Bangladesh.J Nutr. 2012; : 2010-2016https://doi.org/10.3945/jn.112.163634
- The independent effects of maternal obesity and gestational diabetes on the pregnancy outcomes.BMC Endocr Disord. 2014; 14https://doi.org/10.1186/1472-6823-14-47
- Maternal pre-pregnant body mass index, maternal weight change and offspring birthweight.Acta Obstet Gynecol Scand. 2012; 91: 243-249https://doi.org/10.1111/j.1600-0412.2011.01321.x
- Birthweight of offspring and paternal insulin resistance and paternal diabetes in late adulthood: cross sectional survey.Diabetologia. 2004; 47: 12-18https://doi.org/10.1007/s00125-003-1270-x
- Birth Weight of Offspring and Subsequent Cardiovascular Mortality of the Parents.Epidemiology. 2005; 16: 563-569https://doi.org/10.1097/01.ede.0000164790.96316.c0
- Offspring birth weight and risk of mortality from diabetes in mothers.J Epidemiol Community Health. 2011; 65: 775-779https://doi.org/10.1136/jech.2009.100644
- Association between Infant Birth Weight and Maternal Cardiovascular Risk Factors in the Health, Aging, and Body Composition Study.Ann Epidemiol. 2007; 17: 36-43https://doi.org/10.1016/j.annepidem.2006.02.007
- Newborn Size and Body Composition as Predictors of Insulin Resistance and Diabetes in the Parents: Parthenon Birth Cohort Study, Mysore, India.Diabetes Care. 2012; 35: 1884-1890https://doi.org/10.2337/dc12-0177
- Higher Offspring Birth Weight Predicts the Metabolic Syndrome in Mothers but Not Fathers 8 Years After Delivery: The Pune Children’s Study.Diabetes. 2003; 52: 2090-2096
- Birthweight of Offspring, Maternal Pre-pregnancy Characteristics and Mortality of Mothers: the Jerusalem Perinatal Study Cohort.Ann Epidemiol. 2010; 19: 112-117https://doi.org/10.1016/j.annepidem.2008.11.002
- Birth Weight of Offspring and Subsequent Cardiovascular Mortality of the Parents.Epidemiology. 2005; 16: 563-569https://doi.org/10.1097/01.ede.0000164790.96316.c0
- Addressing malnutrition while avoiding obesity: minding the balance.Eur J Clin Nutr. 2013; 67: 513-517https://doi.org/10.1038/ejcn.2012.190
Gobierno de Chile. Encuesta Nacional de Salud. Chile 2009–2010. Santiago de Chile; 2010.
- Effect of growth on cardiometabolic status at 4 y of age.Am J Clin Nutr. 2009; 90: 547-555https://doi.org/10.3945/ajcn.2008.27318
- Alarming weight gain in women of a post-transitional country.Public Health Nutr. 2014; 17: 667-673https://doi.org/10.1017/S1368980013000098
- Evolution of the nutritional status of Chilean children from preschool to school age: anthropometric results according to the source of the data.Arch Latinoam Nutr. 2010; 60: 155-159
WHO. Physical status: The use and interpretation of anthropometry. Technical Report Series No. 854. Geneva; 1995.
- Diagnosis and Classification of Diabetes Mellitus.Diabetes Care. 2014; 37: S81-S90https://doi.org/10.2337/dc14-S081
- Diagnosis and Management of the Metabolic Syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.Circulation. 2005; 112: 2735-2752https://doi.org/10.1161/CIRCULATIONAHA.105.169404
- Reproducibility and Validitiy of Maternal Recall of Pregnancy-Related Events.Epidemiology. 1999; 10: 774-777
- Models with Transformed Variables: Interpretation and Software.Epidemiology. 2015; 26: 16-17https://doi.org/10.1097/EDE.0000000000000247
WHO Multicentre Growth Reference Study Group. WHO Child Growth Standards: Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: Methods and development. Geneva; 2006.
- Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk.J Am Coll Cardiol. 2012; 59: 635-643https://doi.org/10.1016/j.jacc.2011.08.080
- Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus.Circulation. 2005; 112: 3066-3072https://doi.org/10.1161/CIRCULATIONAHA.105.539528
- Adherence to healthy lifestyle and risk of gestational diabetes mellitus: prospective cohort study.Br Med J. 2014; 5450: 1-11https://doi.org/10.1136/bmj.g5450
- Maternal metabolism and obesity: modifiable determinants of pregnancy outcome.Hum Reprod Update. 2012; 16: 255-275https://doi.org/10.1093/humupd/dmp050
- The risk of metabolic syndrome after gestational diabetes mellitus – a hospital-based cohort study.Diabetol Metab Syndr. 2015; 7: 1-10https://doi.org/10.1186/s13098-015-0038-z
- Metabolic syndrome of weight change from pre-pregnancy to 1–5 years post-partum among Chinese women with prior gestational diabetes.Diabet Med. 2015; 32: 1492-1499https://doi.org/10.1111/dme.12790
- Prevalence of Metabolic Syndrome One Year after Delivery in Finnish Women at Increased Risk for Gestational Diabetes Mellitus during Pregnancy.J Pregnancy. 2013; 2013https://doi.org/10.1155/2013/139049
- Obesity, insulin resistance, and pregnancy outcome.Reproduction. 2010; 140: 365-371https://doi.org/10.1530/REP-10-0088
- Prepregnancy body mass index is an independent risk factor for gestational hypertension, gestational diabetes, preterm labor, and small- and large-for-gestational-age infants.J Matern Neonatal Med. 2014; 7058: 1-8https://doi.org/10.3109/14767058.2014.964675
- Postpartum Weight Retention is Associated with Elevated Ratio of Oxidized LDL Lipids to HDL-Cholesterol.Lipids. 2013; 48: 1227-1235https://doi.org/10.1007/s11745-013-3852-9
- Offspring birth weight and maternal fasting lipids in women screened for gestational diabetes mellitus (GDM).Eur J Obstet Gynecol Reprod Biol. 2013; 170: 67-70https://doi.org/10.1016/j.ejogrb.2013.04.015
- Early pregnancy fasting plasma glucose and lipid concentrations in pregnancy and association to offspring size: a retrospective cohort study.BMC Pregnancy Childbirth. 2016; 16: 56https://doi.org/10.1186/s12884-016-0846-7
- Maternal Hypertriglyceridemia: A Link between Maternal Overweight-Obesity and Macrosomia in Gestational Diabetes.Obesity. 2014; 22: 2156-2163https://doi.org/10.1002/oby.20816
Institute of Medicine and National Research Council of the National Academies. Weight gain during pregnancy. Reexamining the guidelines. Washington, DC: National Academies Press (US); 2009.
- Associations of gestational weight gain with maternal body mass index, waist circumference, and blood pressure measured 16 y after pregnancy: the Avon Longitudinal Study of Parents and Children (ALSPAC).Am J Clin Nutr. 2011; 93: 1-4https://doi.org/10.3945/ajcn.110.008326
- Associations between gestational weight gain and BMI, abdominal adiposity, and traditional measures of cardiometabolic risk in mothers.Am J Clin Nutr. 2013; 98: 1218-1225https://doi.org/10.3945/ajcn.112.055772
- Developmental Trajectories of Postpartum Weight 3 Years After Birth: Norwegian Mother and Child Cohort Study.Matern Child Health J. 2014; https://doi.org/10.1007/s10995-014-1593-x
- How do pregnancy-related weight changes and breastfeeding relate to maternal weight and BMI-adjusted waist circumference 7 y after delivery ? Results from a path analysis.Am J Clin Nutr. 2014; 99: 312-319https://doi.org/10.3945/ajcn.113.067405
- IGF2 DNA methylation is a modulator of newborn’s fetal growth and development.Epigenetics. 2012; 7: 1125-1132https://doi.org/10.4161/epi.21855
- Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of Parents and Children.Int J Epidemiol. 2015; 44: 1288-1304https://doi.org/10.1093/ije/dyv042
Article info
Publication history
Published online: February 05, 2018
Accepted:
January 26,
2018
Received in revised form:
December 12,
2017
Received:
December 28,
2016
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
