Highlights
- •Saxagliptin effectively controls glucose levels without affecting the body weight.
- •Saxagliptin also improves patients’ insulin resistance and β-cell function.
- •Saxagliptin monotherapy can prevent or delay the progression of IGT or IFG to T2DM in obese patients.
- •Saxagliptin monotherapy is a credible alternative to metformin in obese pre-diabetic patients.
Abstract
Aims
To assess the effect of saxagliptin monotherapy on blood glucose and islet β-cell
function in obese patients with newly diagnosed pre-diabetes and abnormal fat metabolism.
Methods
A 24-week, randomized controlled trial was conducted involving 25 obese subjects with
impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) (mean age 45 years) to receive lifestyle intervention only (control group) or combined with saxagliptin
2.5 mg or 5 mg daily (S2.5 or S5 group), metformin 1500 mg daily (Met group). Anthropometrics, body fat and biochemical parameters were measured
before and after 4, 12 and 24 weeks intervention.
Results
S5 group and Met group showed a significant decrease in fasting plasma glucose (FPG)
and HbA1c compared with the control group (all P < 0.05) after 24-week intervention. However, the decrease in 2 h postprandial plasma glucose levels (2 h PPG) in S5 group were greater compared with control group (P < 0.01). Insulin resistance (HOMA-IR) was reduced in S5 group, Met group and control
group (P < 0.05), and the β-cell function (HOMA-β) was improved in all groups (P < 0.05). However, the changes in obesity-related indicators including waist circumference,
hip circumference, weight, BMI, body fat, percentage of body fat and waist-to-hip
fat ratio were greate in Met group (all P < 0.05) compared with other groups (P > 0.05).
Conclusions
Saxagliptin monotherapy may prevent or delay the progression of IGT or IFG to type
2 diabetes mellitus in obese patients with newly diagnosed pre-diabetes.
ClinicalTrials.gov: NCT01960205.
Keywords
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Article info
Publication history
Published online: May 12, 2017
Accepted:
May 8,
2017
Received in revised form:
April 21,
2017
Received:
December 28,
2016
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
