Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials

  • Farideh Shishehbor
    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
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  • Anahita Mansoori
    Corresponding author at: Department of Nutrition, Para-Medical School, Ahvaz Jundishapur University of Medical Sciences, P.O. BOX: 61357-15794, Ahvaz, Khuzestan, Iran. Fax: +98 61 33738330.
    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
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  • Fatemeh Shirani
    Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
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      • Vinegar consumption can reduce the postprandial glucose response in both healthy, and participants with glucose disorder.
      • Vinegar consumption can reduce the postprandial insulin response.
      • Type of vinegar and disorders of glucose homeostasis could influence the heterogeneity of studies.



      Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in several trials with conflicting results.

      Research methods and procedures

      The purpose of the current study was to systematically review control trials that report on the effect of vinegar intake on postprandial glucose response. Postprandial insulin response was considered as secondary outcome.


      The pooled analysis of studies revealed a significant mean glucose and insulin area under the curve (AUC) reduction in participants who consumed vinegar compared with the control group (standard mean difference = −0.60, 95%CI −1.08 to −0.11, p = 0.01 and −1.30, 95%CI −1.98 to −0.62, p < 0.001, respectively).


      The findings suggest that vinegar can be effective in reducing postprandial glucose and insulin levels, indicating it could be considered as an adjunctive tool for improving glycemic control.


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