- •Irisin levels were significantly elevated after CSII treatment in T2DM patients.
- •Elevated irisin was accompanied by improved glycemic control and lipid profiles.
- •Elevated irisin may represent benefits of ameliorative metabolism following CSII.
Irisin, identified as a novel myokine, plays an important role in improving metabolic disorders, including type 2 diabetes mellitus (T2DM). In this interventional study, we investigated the alteration of serum irisin levels in T2DM subjects after transient continuous subcutaneous insulin infusion (CSII) treatment.
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Published online: January 30, 2016
Accepted: January 22, 2016
Received in revised form: January 17, 2016
Received: August 13, 2015
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.