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Brief report| Volume 113, P33-37, March 2016

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Endothelin-1 as a predictor of impaired glucose tolerance and type 2 diabetes – A longitudinal study in the Vara-Skövde Cohort

  • Author Footnotes
    1 These authors are contributed equally to this study.
    Josefin Olausson
    Footnotes
    1 These authors are contributed equally to this study.
    Affiliations
    The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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  • Author Footnotes
    1 These authors are contributed equally to this study.
    Bledar Daka
    Footnotes
    1 These authors are contributed equally to this study.
    Affiliations
    Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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  • Margareta I. Hellgren
    Affiliations
    Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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  • Charlotte A. Larsson
    Affiliations
    Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

    Social Medicine and Global Health, Department of Clinical Sciences, Malmö, Lund University, Sweden
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  • Max Petzold
    Affiliations
    Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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  • Ulf Lindblad
    Affiliations
    Institute of Medicine, Department of Public Health and Community Medicine/Primary Health Care, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
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  • Per-Anders Jansson
    Correspondence
    Corresponding author at: Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, Bruna Stråket 16, S-413 45 Gothenburg, Sweden. Tel.: +46 031 342 73 26.
    Affiliations
    The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
    Search for articles by this author
  • Author Footnotes
    1 These authors are contributed equally to this study.
Published:January 30, 2016DOI:https://doi.org/10.1016/j.diabres.2016.01.027

      Highlights

      • Endothelin-1 may predict impaired glucose tolerance and type 2 diabetes in women.
      • Endothelin-1 and impaired glucose metabolism (IGM) was not associated in men.
      • Endothelin-1 exhibits apparent sex differences as a predictor of IGM.

      Abstract

      We addressed whether endothelin-1, a marker of endothelial dysfunction, predicts impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) in a population study in south-western Sweden. Follow-up after 9.7 years showed an association between circulating endothelin-1 levels at baseline and development of IGT/T2DM in women but not in men.

      Abbreviations:

      T2DM (type 2 diabetes mellitus), IGT (impaired glucose tolerance)

      Keywords

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