- •Postprandial hypotension is defined as fall in BP ≥ 20 mmHg post-meal.
- •It is common in diabetes, often with serious consequences.
- •Gastric emptying varies widely (1–4 kcal/min) impacting duodenal nutrient delivery.
- •The fall in BP is greater at duodenal rate of 4 kcal/min in diabetes.
- •Slowing gastric emptying may help in management of postprandial hypotension.
Postprandial hypotension occurs frequently in diabetes. We show in 9 type 2 patients, that the fall in systolic blood pressure is greater in response to intraduodenal glucose infused at 4 kcal/min than 2 kcal/min, implying that strategies to slow gastric emptying may be effective in the management of postprandial hypotension.
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Published online: January 22, 2016
Accepted: January 17, 2016
Received in revised form: January 14, 2016
Received: October 21, 2015
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.