Highlights
- •Postprandial hypotension is defined as fall in BP ≥ 20 mmHg post-meal.
- •It is common in diabetes, often with serious consequences.
- •Gastric emptying varies widely (1–4 kcal/min) impacting duodenal nutrient delivery.
- •The fall in BP is greater at duodenal rate of 4 kcal/min in diabetes.
- •Slowing gastric emptying may help in management of postprandial hypotension.
Abstract
Postprandial hypotension occurs frequently in diabetes. We show in 9 type 2 patients,
that the fall in systolic blood pressure is greater in response to intraduodenal glucose
infused at 4 kcal/min than 2 kcal/min, implying that strategies to slow gastric emptying may be effective in the
management of postprandial hypotension.
Keywords
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Article info
Publication history
Published online: January 22, 2016
Accepted:
January 17,
2016
Received in revised form:
January 14,
2016
Received:
October 21,
2015
Identification
Copyright
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
