Highlights
- •The role for DPP-4 in type 1 diabetes is still not clarified.
- •Serum DPP-4 activity was evaluated in young-adult type 1 diabetes patients.
- •DPP-4 activity was significantly elevated in type 1 diabetes compared to controls.
- •DPP-4 activity was correlated with duration of diabetes and GGT level, but not HbA1c.
- •The results suggest a potential implication of DPP-4 in type 1 diabetes.
Abstract
Aims
Currently, inhibition of dipeptidyl peptidase-4 (DPP-4) is widely used in the treatment
of type 2 diabetes. Application of this strategy is awaited as a new therapeutic approach
for type 1 diabetes, but the scientific basis is still lacking. This report describes
the evaluation of serum DPP-4 activity in type 1 diabetes compared with control subjects,
and assessment of relationships between DPP-4 activity and diabetic complication markers
and metabolic variables in type 1 diabetes.
Methods
We examined serum DPP-4 activity in Japanese young-adult type 1 diabetes (n = 76, females 69.7%, age 30.9 ± 6.2 years, duration of diabetes 16.5 ± 11.1 years; mean ± SD) and healthy controls (n = 22). Association of the enzymatic activity with diabetic micro- and macro- vascular
complication markers and clinical parameters was also assessed.
Results
Subjects with type 1 diabetes displayed significantly higher serum DPP-4 activity
than healthy controls (relative value, control: 1.00 ± 0.28, T1D, 1.29 ± 0.38; p = 0.0011) independent of other clinical parameters. In type 1 diabetes, DPP-4 activity
was positively correlated with duration of diabetes (r = 0.248, p = 0.031), while not correlated with HbA1c level. In univariate correlation analysis
of diabetic complication markers and other metabolic parameters, coefficient of variation
of R-R intervals (CVR-R) and gamma (γ)-glutamyltransferase (GGT) levels were correlated
with DPP-4 activity. GGT was extracted as an independent variable of DPP-4 activity
in multivariate analysis (β = 0.213, p = 0.035).
Conclusions
Serum DPP-4 activity is significantly elevated in Japanese type 1 diabetes, suggesting
pathophysiological significance of the enzyme in type 1 diabetes.
Keywords
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Article info
Publication history
Published online: January 14, 2016
Accepted:
December 26,
2015
Received in revised form:
December 16,
2015
Received:
October 9,
2015
Identification
Copyright
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
