- •Prolongation of QT interval can occur with hypoglycaemia in people with diabetes.
- •Hyperglycaemia had no direct effect on the QTc.
- •Many hypoglycaemic episodes occur without symptoms.
This study using simultaneous Holter and continuous glucose monitoring demonstrates that prolongation of QT interval can occur with hypoglycaemia in an ambulatory setting in people with type 1 and type 2 diabetes treated with insulin. This highlights the potential proarrhythmic harms associated with hypoglycaemia.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Diabetes Research and Clinical Practice
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Altered ventricular repolarization during hypoglycaemia in patients with diabetes.Diabetic Med. 1997; 14: 648-654
- Cardiac arrhythmia and nocturnal hypoglycaemia in type 1 diabetes—the ‘dead in bed’ syndrome revisited.Diabetologia. 2009; 52: 42-45
- Risk of cardiac arrhythmias during hypoglycemia in patients with type 2 diabetes and cardiovascular risk.Diabetes. 2014; 63: 1738-1747
- Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring.Diabetes Care. 2003; 26: 1485-1489
- Relationship between hypoglycemic episodes and ventricular arrhythmias in patients with type 2 diabetes and cardiovascular diseases: silent hypoglycemias and silent arrhythmias.Diabetes Care. 2014; 37: 516-520
- Prolonged QTc interval predicts mortality in patients with type 1 diabetes mellitus.Diabetic Med. 2001; 18: 199-205
- Continuous glucose monitoring reveals associations of glucose levels with QT interval length.Diabetes Technol Ther. 2010; 12: 283-286
Published online: January 12, 2016
Accepted: January 5, 2016
Received in revised form: November 17, 2015
Received: September 6, 2015
© 2016 Published by Elsevier Inc. All rights reserved.