Highlights
- •Increased circulating vaspin levels were associated with CAD prevalence in T2DM patients.
- •The vaspin level was a determining factor for CAD with type 2 diabetes.
- •Vaspin is positively correlated with high BMI and T2DM.
Abstract
Aim
Adipokines contribute to the atherosclerotic process, connecting obesity and diabetes
to cardiovascular disease. Vaspin is a recently discovered adipokine, so data about
the relationship of vaspin to coronary artery disease in type-2 diabetes mellitus
(T2DM) is limited. The current study was designed to evaluate the association of vaspin
with the presence of coronary artery disease in T2DM.
Methods
We enrolled 228 patients with T2DM, with or without CAD, between March 2010 and July
2011, and 120 healthy control participants. Serum vaspin, homeostasis model assessment
of insulin resistance (HOMA-IR) and other cardiovascular risk factors were assayed.
Results
Vaspin levels were significantly increased in patients with T2DM compared to healthy
individuals, and were further increased in patients with both T2DM and CAD compared
to those with T2DM but without CAD. Moreover, vaspin correlated positively with body
mass index, fasting plasma glucose, insulin and HOMA-IR in all patients with T2DM
(P < 0.05). Furthermore, in multivariate logistic regression analysis, vaspin level was
associated with the presence of CAD in patients with T2DM.
Conclusions
Vaspin correlates with CAD in T2DM.
Keywords
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Article info
Publication history
Published online: January 28, 2016
Accepted:
December 26,
2015
Received in revised form:
December 7,
2015
Received:
July 20,
2015
Identification
Copyright
© 2016 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
