Advertisement

Prediabetes is not independently associated with microalbuminuria in Korean general population: The Korea National Health and Nutrition Examination Survey 2011–2012 (KNHANES V-2,3)

  • Chul-Hee Kim
    Correspondence
    Corresponding author at: Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Wonmi-gu, Bucheon 420-767, South Korea. Tel.: +82 32 621 5155; fax: +82 32 621 5018.
    Affiliations
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
    Search for articles by this author
  • Kyu-Jin Kim
    Affiliations
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
    Search for articles by this author
  • Bo-Yeon Kim
    Affiliations
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
    Search for articles by this author
  • Chan-Hee Jung
    Affiliations
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
    Search for articles by this author
  • Ji-Oh Mok
    Affiliations
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
    Search for articles by this author
  • Sung-Koo Kang
    Affiliations
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, South Korea
    Search for articles by this author
  • Hong-Kyu Kim
    Affiliations
    Health Screening & Promotion Center, Asan Medical Center, Seoul, South Korea
    Search for articles by this author
Published:September 19, 2014DOI:https://doi.org/10.1016/j.diabres.2014.09.004

      Abstract

      We investigated the association between microalbuminuria and prediabetes in Korean population using data from the KNHANES 2011–2012. Prevalence of microalbuminuria was significantly increased in prediabetes group. However, the odds ratio became insignificant after adjustment for blood pressure, and the prevalence of microalbuminuria was not increased in prediabetic subjects without hypertension.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Diabetes Research and Clinical Practice
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Cirillo M.
        • Senigalliesi L.
        • Laurenzi M.
        • Alfieri R.
        • Stamler J.
        • Stamler R.
        • et al.
        Microalbuminuria in nondiabetic adults: relation of blood pressure, body mass index, plasma cholesterol levels, and smoking: the Gubbio Population Study.
        Arch Intern Med. 1998; 158: 1933-1939
        • Mykkanen L.
        • Zaccaro D.J.
        • Wagenknecht L.E.
        • Robbins D.C.
        • Gabriel M.
        • Haffner S.M.
        Microalbuminuria is associated with insulin resistance in nondiabetic subjects: the insulin resistance atherosclerosis study.
        Diabetes. 1998; 47: 793-800
        • Hillege H.L.
        • Janssen W.M.
        • Bak A.A.
        • Diercks G.F.
        • Grobbee D.E.
        • Crijns H.J.
        • et al.
        Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity.
        J Intern Med. 2001; 249: 519-526
        • Kim Y.I.
        • Kim C.H.
        • Choi C.S.
        • Chung Y.E.
        • Lee M.S.
        • Lee S.I.
        • et al.
        Microalbuminuria is associated with the insulin resistance syndrome independent of hypertension and type 2 diabetes in the Korean population.
        Diabetes Res Clin Pract. 2001; 52: 145-152
        • Yuyun M.F.
        • Khaw K.T.
        • Luben R.
        • Welch A.
        • Bingham S.
        • Day N.E.
        • et al.
        Microalbuminuria, cardiovascular risk factors and cardiovascular morbidity in a British population: the EPIC-Norfolk population-based study.
        Eur J Cardiovasc Prev Rehabil. 2004; 11: 207-213
        • Kweon S.S.
        • Shin M.H.
        • Choi J.S.
        • Nam H.S.
        • Lee Y.H.
        • Park K.S.
        • et al.
        Prevalence of albuminuria and associated cardiovascular risk factors: a community cohort in Namwon City, Korea.
        Diabetes Res Clin Pract. 2012; 97: 492-498
        • Mykkanen L.
        • Haffner S.M.
        • Kuusisto J.
        • Pyorala K.
        • Laakso M.
        Microalbuminuria precedes the development of NIDDM.
        Diabetes. 1994; 43: 552-557
        • Dutta D.
        • Choudhuri S.
        • Mondal S.A.
        • Mukherjee S.
        • Chowdhury S.
        Urinary albumin: creatinine ratio predicts prediabetes progression to diabetes and reversal to normoglycemia: role of associated insulin resistance, inflammatory cytokines and low vitamin D.
        J Diabetes. 2014; 6: 316-322
        • Suzuki H.
        • Fukushima M.
        • Usami M.
        • Ikeda M.
        • Taniguchi A.
        • Nakai Y.
        • et al.
        IGT with fasting hyperglycemia is more strongly associated with microalbuminuria than IGT without fasting hyperglycemia.
        Diabetes Res Clin Pract. 2004; 64: 213-219
        • Wang X.L.
        • Lu J.M.
        • Pan C.Y.
        • Tian H.
        • Li C.L.
        A comparison of urinary albumin excretion rate and microalbuminuria in various glucose tolerance subjects.
        Diabet Med. 2005; 22: 332-335
        • Lu Q.
        • Tong N.
        • Liu Y.
        • Li N.
        • Tang X.
        • Zhao J.
        • et al.
        Community-based population data indicates the significant alterations of insulin resistance, chronic inflammation and urine ACR in IFG combined IGT group among prediabetic population.
        Diabetes Res Clin Pract. 2009; 84: 319-324
        • Sung K.C.
        • Rhee E.J.
        • Kim H.
        • Park J.B.
        • Kim Y.K.
        • Woo S.
        • et al.
        An elevated apolipoprotein B/AI ratio is independently associated with microalbuminuria in male subjects with impaired fasting glucose.
        Nutr Metab Cardiovasc Dis. 2011; 21: 610-616
        • Bahar A.
        • Makhlough A.
        • Yousefi A.
        • Kashi Z.
        • Abediankenari S.
        Correlation between prediabetes conditions and microalbuminuria.
        Nephrourol Mon. 2013; 5: 741-744
        • Kim C.H.
        • Kim H.K.
        • Bae S.J.
        • Park J.Y.
        • Lee K.U.
        Discordance between fasting glucose-based and hemoglobin A1c-based diagnosis of diabetes mellitus in Koreans.
        Diabetes Res Clin Pract. 2011; 91: e8-e10
        • Kim H.K.
        • Bae S.J.
        • Choe J.
        Impact of HbA1c criterion on the detection of subjects with increased risk for diabetes among health check-up recipients in Korea.
        Diabetes Metab J. 2012; 36: 151-156
        • Korea Centers for Disease Control and Prevention
        Korea National Health and Nutrition Examination Survey.
        2012 (http://knhanes.cdc.go.kr/knhanes/ [updated 04.02.14; cited 18.04.14])
        • Korean Ministry of Health and Welfare
        Korea health statistics 2012: Korea National Health and Nutrition Examination Survey (KNHANES V-3).
        Korean Ministry of Health and Welfare, Seoul, Republic of Korea2013
        • Hoffmann I.S.
        • Jimenez E.
        • Cubeddu L.X.
        Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure.
        J Hum Hypertens. 2001; 15: 407-412
        • Won J.C.
        • Lee Y.J.
        • Kim J.M.
        • Han S.Y.
        • Noh J.H.
        • Ko K.S.
        • et al.
        Prevalence of and factors associated with albuminuria in the Korean adult population: the 2011 Korea National Health and Nutrition Examination Survey.
        PLOS ONE. 2013; 8: e83273
        • Nam G.E.
        • Han K.
        • Park Y.G.
        • Kim Y.H.
        • Han B.
        • Kim S.M.
        • et al.
        Prevalence and related risk factors of albuminuria in Korean adults: the 2011 Korea National Health and Nutrition Examination Survey.
        Nephron Clin Pract. 2013; 124: 232-238