Abstract
Aims
Several randomized trials with metabolic outcomes have reported that glucagon like
peptide-1 receptor agonists (GLP-1 RA) could be associated with an increased risk
of pancreatitis. The present meta-analysis aimed to examine this hypothesis.
Methods
An extensive Medline, Embase, and Cochrane Database search for “exenatide”, “liraglutide”,
“albiglutide”, “taspoglutide”, “dulaglutide”, “lixisenatide”, and “semaglutide” was
performed up to March 31st, 2013. Inclusion criteria: (i) randomized trials, (ii)
duration ≥12 weeks; (iii) on type 2 diabetes; and (iv) comparison of GLP-1RA with
placebo or active drugs. Mantel–Haenszel odds ratio with 95% confidence interval (MH-OR)
was calculated for pancreatitis.
Results
80 eligible trials were identified. Of these, 39 had not disclosed their findings
or did not report any information on pancreatitis. The remaining 41 trials enrolled
14,972 patients, with a total exposure of 14,333 patient × years (8353 and 5980 patient × years for GLP-1 receptor agonists and comparators, respectively). The overall risk
of pancreatitis was not different between GLP-1RA and comparators (MH-OR: 1.01[0.37;
2.76]; p = 0.99).
Conclusions
The present meta-analysis does not suggest any increase in the risk of pancreatitis
with the use of GLP-1RA. However, it should be recognized that the number of observed
cases of incident pancreatitis is very small and the confidence intervals of risk
estimates are wide.
Keywords
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Article info
Publication history
Published online: January 31, 2014
Accepted:
January 4,
2014
Received in revised form:
May 2,
2013
Received:
May 2,
2013
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
