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Research Article| Volume 103, ISSUE 2, P319-327, February 2014

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Trends in the prevalence of diabetes and impaired fasting glucose in association with obesity in Iran: 2005–2011

Published:January 21, 2014DOI:https://doi.org/10.1016/j.diabres.2013.12.034

      Abstract

      Aims

      To estimate the prevalence and trends of diabetes mellitus (DM) and impaired fasting glucose (IFG), 2005–2011, and to determine the contribution of obesity to DM prevalence.

      Patients and methods

      Data from Surveillance of Risk Factors of Non-communicable Diseases (SuRFNCD) conducted in 2005, 2007, and 2011 were gathered. DM was defined as presence of self-reported previous diagnosis or a fasting plasma glucose (FPG) ≥ 7 mmol/L. IFG was diagnosed with FPG levels between 5.6 and 6.9 mmol/L. Prevalence rates for 2011 and trends for 2005–2011 were determined by extrapolating survey results to Iran's adult population. Population attributable fraction (PAF) of obesity was also calculated.

      Results

      In 2011, IFG and total DM prevalence rates were 14.60% (95%CI: 12.41–16.78) and 11.37% (95%CI: 9.86–12.89) among 25–70 years, respectively. DM was more common in older age (p < 0.0001), in women (p = 0.0216), and in urban-dwellers (p = 0.0001).
      In 2005–2011, trend analysis revealed a 35.1% increase in DM prevalence (OR: 1.04, 95%CI: 1.01–1.07, p = 0.011); albeit, IFG prevalence remained relatively unchanged (OR: 0.98, 95%CI: 0.95–1.00, p = 0.167). In this period, DM awareness improved; undiagnosed DM prevalence decreased from 45.7% to 24.7% (p < 0.001). PAF analysis demonstrated that 33.78%, 10.25%, and 30.56% of the prevalent DM can be attributed to overweight (BMI ≥ 25 kg/m2), general obesity (BMI ≥ 30 kg/m2), and central obesity (waist circumference ≥ 90 cm), respectively. Additionally, the DM increase rate in 2005–2011, was 20 times higher in morbidly obese compared with lean individuals.

      Conclusion

      More than four million Iranian adults have DM which has increased by 35% over the past seven years, owing in large part, to expanding obesity epidemic.

      Keywords

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      References

        • International Diabetes Federation
        IDF diabetes atlas.
        International Diabetes Federation, Brussels2011
        • Guariguata L.
        By the numbers: new estimates from the IDF Diabetes Atlas Update for 2012.
        Diabetes Res Clin Pract. 2012; 98: 524-525
        • Esteghamati A.
        • Meysamie A.
        • Khalilzadeh O.
        • Rashidi A.
        • Haghazali M.
        • Asgari F.
        • et al.
        Third national Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007) in Iran: methods and results on prevalence of diabetes, hypertension, obesity, central obesity, and dyslipidemia.
        BMC Public Health. 2009; 9: 167
        • Wang Y.
        • Mi J.
        • Shan X.Y.
        • Wang Q.J.
        • Ge K.Y.
        Is China facing an obesity epidemic and the consequences? The trends in obesity and chronic disease in China.
        Int J Obes. 2007; 31: 177-188
        • Gonzalez E.L.
        • Johansson S.
        • Wallander M.A.
        • Rodriguez L.A.
        Trends in the prevalence and incidence of diabetes in the UK: 1996–2005.
        J Epidemiol Community Health. 2009; 63: 332-336
        • Lipscombe L.L.
        • Hux J.E.
        Trends in diabetes prevalence, incidence, and mortality in Ontario, Canada 1995–2005: a population-based study.
        Lancet. 2007; 369: 750-756
        • American Diabetes Association
        Economic costs of diabetes in the U.S. in 2007.
        Diabetes Care. 2008; 31: 596-615
        • Esteghamati A.
        • Khalilzadeh O.
        • Anvari M.
        • Meysamie A.
        • Abbasi M.
        • Forouzanfar M.
        • et al.
        The economic costs of diabetes: a population-based study in Tehran, Iran.
        Diabetologia. 2009; 52: 1520-1527
        • Shaw J.
        • Sicree R.
        • Zimmet P.
        Global estimates of the prevalence of diabetes for 2010 and 2030.
        Diabetes Res Clin Pract. 2010; 87: 4-14
        • Nichols G.A.
        • Brown J.B.
        Higher medical care costs accompany impaired fasting glucose.
        Diabetes Care. 2005; 28: 2223-2229
        • Nathan D.M.
        • Davidson M.B.
        • DeFronzo R.A.
        • Heine R.J.
        • Henry R.R.
        • Pratley R.
        • et al.
        Impaired fasting glucose and impaired glucose tolerance implications for care.
        Diabetes Care. 2007; 30: 753-759
        • Hossain P.
        • Kawar B.
        • El Nahas M.
        Obesity and diabetes in the developing world—a growing challenge.
        N Engl J Med. 2007; 356: 213-215
        • Esteghamati A.
        • Khalilzadeh O.
        • Mohammad K.
        • Meysamie A.
        • Rashidi A.
        • Kamgar M.
        • et al.
        Secular trends of obesity in Iran between 1999 and 2007: national surveys of risk factors of non-communicable diseases.
        Metab Syndr Relat Disord. 2010; 8: 209-213
        • Chan J.M.
        • Rimm E.B.
        • Colditz G.A.
        • Stampfer M.J.
        • Willett W.C.
        Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men.
        Diabetes Care. 1994; 17: 961-969
        • Nagaya T.
        • Yoshida H.
        • Takahashi H.
        • Kawai M.
        Increases in body mass index, even within non-obese levels, raise the risk for Type 2 diabetes mellitus: a follow-up study in a Japanese population.
        Diabet Med. 2005; 22: 1107-1111
        • Esteghamati A.
        • Gouya M.M.
        • Abbasi M.
        • Delavari A.
        • Alikhani S.
        • Alaedini F.
        • et al.
        Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran.
        Diabetes Care. 2008; 31: 96-98
        • Esteghamati A.
        • Ashraf H.
        • Rashidi A.
        • Meysamie A.
        Waist circumference cut-off points for the diagnosis of metabolic syndrome in Iranian adults.
        Diabetes Res Clin Pract. 2008; 82: 104-107
        • Statistical Centre of Iran
        Results of 2011 National Census by Age, Sex, Area of Residence, and Province.
        2014 (www.amar.org.ir/Default.aspx?tabid=765)
        • Cowie C.C.
        • Rust K.F.
        • Ford E.S.
        • Eberhardt M.S.
        • Byrd-Holt D.D.
        • Li C.
        • et al.
        Full accounting of diabetes and pre-diabetes in the US population in 1988–1994 and 2005–2006.
        Diabetes Care. 2009; 32: 287-294
        • Whiting D.R.
        • Guariguata L.
        • Weil C.
        • Shaw J.
        IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030.
        Diabetes Res Clin Pract. 2011; 94: 311-321
        • Shera A.S.
        • Jawad F.
        • Maqsood A.
        Prevalence of diabetes in Pakistan.
        Diabetes Res Clin Pract. 2007; 76: 219-222
        • Satman I.
        • Yilmaz T.
        • Sengul A.
        • Salman S.
        • Salman F.
        • Uygur S.
        • et al.
        Population-based study of diabetes and risk characteristics in Turkey: results of the Turkish diabetes epidemiology study (TURDEP).
        Diabetes Care. 2002; 25: 1551-1556
        • Ashraf H.
        • Rashidi A.
        • Noshad S.
        • Khalilzadeh O.
        • Esteghamati A.
        Epidemiology and risk factors of the cardiometabolic syndrome in the Middle East.
        Expert Rev Cardiovasc Ther. 2011; 9: 309-320
        • Chodick G.
        • Heymann A.D.
        • Shalev V.
        • Kookia E.
        The epidemiology of diabetes in a large Israeli HMO.
        Eur J Epidemiol. 2003; 18: 1143-1146
        • al-Mahroos F.
        • McKeigue P.M.
        High prevalence of diabetes in Bahrainis. Associations with ethnicity and raised plasma cholesterol.
        Diabetes Care. 1998; 21: 936-942
        • Motlagh B.
        • O’Donnell M.
        • Yusuf S.
        Prevalence of cardiovascular risk factors in the Middle East: a systematic review.
        Eur J Cardiovasc Prev Rehabil. 2009; 16: 268-280
        • Danaei G.
        • Finucane M.M.
        • Lu Y.
        • Singh G.M.
        • Cowan M.J.
        • Paciorek C.J.
        • et al.
        National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants.
        Lancet. 2011; 378: 31-40
        • Esteghamati A.
        • Khalilzadeh O.
        • Rashidi A.
        • Kamgar M.
        • Meysamie A.
        • Abbasi M.
        Physical activity in Iran: results of the third national surveillance of risk factors of non-communicable diseases (SuRFNCD-2007).
        J Phys Act Health. 2011; 8: 27-35
        • Ghassemi H.
        • Harrison G.
        • Mohammad K.
        An accelerated nutrition transition in Iran.
        Public Health Nutr. 2002; 5: 149-155
        • McBean A.M.
        • Li S.
        • Gilbertson D.T.
        • Collins A.J.
        Differences in diabetes prevalence, incidence, and mortality among the elderly of four racial/ethnic groups: Whites, Blacks, Hispanics, and Asians.
        Diabetes Care. 2004; 27: 2317-2324
        • Wild S.
        • Roglic G.
        • Green A.
        • Sicree R.
        • King H.
        Global prevalence of diabetes estimates for the year 2000 and projections for 2030.
        Diabetes Care. 2004; 27: 1047-1053
        • King H.
        • Rewers M.
        Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults. WHO Ad Hoc Diabetes Reporting Group.
        Diabetes Care. 1993; 16: 157-177
        • Ford E.S.
        • Williamson D.F.
        • Liu S.
        Weight change and diabetes incidence: findings from a national cohort of US adults.
        Am J Epidemiol. 1997; 146: 214-222
        • Hu G.
        • Lindstrom J.
        • Valle T.T.
        • Eriksson J.G.
        • Jousilahti P.
        • Silventoinen K.
        • et al.
        Physical activity, body mass index, and risk of type 2 diabetes in patients with normal or impaired glucose regulation.
        Arch Intern Med. 2004; 164: 892
        • Knowler W.C.
        • Barrett-Connor E.
        • Fowler S.E.
        • Hamman R.F.
        • Lachin J.M.
        • Walker E.A.
        • et al.
        Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin.
        N Engl J Med. 2002; 346: 393-403
        • Narayan K.M.V.
        • Boyle J.P.
        • Thompson T.J.
        • Gregg E.W.
        • Williamson D.F.
        Effect of BMI on lifetime risk for diabetes in the US.
        Diabetes Care. 2007; 30: 1562-1566
        • Berg C.
        • Rosengren A.
        • Aires N.
        • Lappas G.
        • Torén K.
        • Thelle D.
        • et al.
        Trends in overweight and obesity from 1985 to 2002 in Göteborg, West Sweden.
        Int J Obes. 2005; 29: 916-924
        • Hart C.
        • Hole D.
        • Lawlor D.
        • Davey Smith G.
        How many cases of type 2 diabetes mellitus are due to being overweight in middle age? Evidence from the Midspan prospective cohort studies using mention of diabetes mellitus on hospital discharge or death records.
        Diabet Med. 2007; 24: 73-80
        • Zandieh A.
        • Esteghamati A.
        • Morteza A.
        • Noshad S.
        • Khalilzadeh O.
        • Gouya M.M.
        • et al.
        Appropriate BMI cut-off values for identification of metabolic risk factors: third national surveillance of risk factors of non-communicable diseases in Iran (SuRFNCD-2007).
        Ann Hum Biol. 2012; 39: 484-489
        • American Diabetes Association
        Diagnosis and classification of diabetes mellitus.
        Diabetes Care. 2010; 33: S62-S69
        • American Diabetes Association
        Standards of medical care in diabetes – 2013.
        Diabetes Care. 2013; 36: S11-S66