Abstract
To explore the utility of the HbA1c criterion in the definition of metabolic syndrome
(MS) in Koreans, we cross-sectionally analyzed clinical and laboratory data on 11,293
non-diabetic Korean adults (aged 20–89 years, 34% women) collected during regular health checkups. Dysglycemia was defined
as either fasting plasma glucose (FPG) ≥5.6 mmol/l or HbA1c ≥5.7%. The prevalence of MS as judged by the HbA1c criterion alone
(17.8%) was significantly less than that determined by FPG level alone (24.5%). Use
of a combination of both criteria slightly increased the prevalence of MS (26.0%).
Among the 2953 subjects categorized as having MS using the combined criteria, 929
(31%) were diagnosed by the FPG criterion alone, 177 (6%) by the HbA1c criterion alone,
and 1847 (63%) using both criteria. The group diagnosed using FPG values alone had
significantly higher BMI, waist circumference, blood pressure, fasting plasma insulin
levels, and insulin resistance index compared with those in the group diagnosed using
HbA1c levels alone. In men, the brachial-ankle pulse wave velocity was significantly
higher and the HDL-cholesterol level was lower in the HbA1c-alone group. Therefore,
employment of the HbA1c criterion may be useful to define MS in subjects at increased
risk for atherosclerosis.
Keywords
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Article info
Publication history
Published online: November 09, 2011
Accepted:
October 10,
2011
Received in revised form:
September 10,
2011
Received:
July 11,
2011
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
