Abstract
Aim
The aim of this study was to evaluate the relationship between sublinical inflammation
and glycemic status in patients with gestational diabetes mellitus (GDM).
Methods
Sixty-one patients with GDM and 40 healthy pregnant women were included in the study.
Fasting blood glucose (FBG), insulin, high sensitivity C-reactive protein (hsCRP),
lipid parameters and carotid artery intima-media thickness (CIMT) were measured. Fifty-five
of the patients with GDM returned for a follow-up visit scheduled at 1-year post-partum.
These patients were subjected to 75 g oral glucose tolerance test (OGTT) followed by an evaluation of metabolic and subclinical
inflammatory parameters were evaluated.
Results
The mean FBG, insulin, homeostasis model assessment insulin resistance (HOMA-IR),
triglyceride (TG), hsCRP levels and CIMT in the women with GDM were significantly
higher than those in the control group. C-reactive protein and CIMT were positively
correlated with insulin, HOMA-IR, glucose value at the time of the OGTT 50, prepregnancy
body mass index, TG and FBG. Multivariate logistic regression analysis on patients
with sustained hyperglycemia one-year postpartum revealed elevated hsCRP levels to
be independent risk factors for the development of dysglycemia.
Conclusions
Elevated hsCRP levels could be predictors of progression to T2DM later in life in
patients with GDM.
Keywords
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Article info
Publication history
Published online: September 14, 2011
Accepted:
August 23,
2011
Received in revised form:
August 18,
2011
Received:
June 27,
2011
Identification
Copyright
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
