A glycated hemoglobin (HbA1c) range of 5.7–6.4% has been included as a category of increased risk for diabetes. We evaluated whether or not it is reasonable to apply this HbA1c range to Koreans.
A retrospective analysis was conducted among subjects who participated in comprehensive health check-ups annually for 5 years. A total of 9723 subjects were classified into 12 categories based on the baseline HbA1c level.
During 4 years, 601 of the 9723 subjects (6.2%) developed diabetes. Based on ROC analysis, a HbA1c of 5.7% gave an optimal sensitivity of 62% and specificity of 85% to predict diabetes. The point showing a substantial difference in the Kaplan-Meier curves was a HbA1c of 5.7%. The incidence of diabetes was 20.8% among subjects with a baseline HbA1c of 5.7–6.4%. The hazard ratio of developing diabetes was 6.5 (95% CI, 3.7–10.2) in the subjects with a HbA1c of 5.7% compared with the bottom category of HbA1c (<5.0%).
A HbA1c cut-point of 5.7% is a suitable value for predicting future diabetes. It is reasonable to consider a HbA1c range of 5.7–6.4% as a category of increased risk for diabetes in Korean, similar to an IFG or IGT.
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Published online: June 15, 2011
Accepted: May 19, 2011
Received: March 4, 2011
☆This work was partially supported by the Samsung Biomedical Research Institute Grant (SBRI C-A8-223-2). Parts of this study were presented in abstract form at the 8th International Diabetes Federation-Western Pacific Region Congress, Busan, Korea, 17–20 October 2010.
© 2011 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.