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Prevalence and risk factors of metabolic syndrome among Asian Indians: A community survey

      Abstract

      Aim

      To determine the prevalence of and risk factors for metabolic syndrome (MS) among urban Asian Indian adults.

      Methods

      2225 subjects aged ≥20 years were studied in a population based cross-sectional survey in Chandigarh, a city in north India. Anthropometric measurements, estimation of capillary plasma glucose, HDL cholesterol and triglycerides were done. Metabolic syndrome prevalence was estimated using National Cholesterol Education Program-Adult Treatment Panel III (NCEP ATP III), modified NCEP ATP III and International Diabetes Federation (IDF) criteria. Multiple logistic regression analysis was done to find out risk factors for metabolic syndrome.

      Results

      The prevalence rates of metabolic syndrome were 35.8% (NCEP ATP III), 45.3% (modified NCEP ATP III) and 39.5% (IDF criteria). As per modified NCEP ATP III criteria, central obesity was the commonest abnormality among females and elevated blood pressure among males. Risk factors for MS were increasing age, female gender, sedentary lifestyle and diabetes in parents.

      Conclusions

      Our study showed a high prevalence of metabolic syndrome and its individual components. Independent risk factors for metabolic syndrome included increasing age, female gender, sedentary lifestyle and diabetes mellitus in parents.

      Keywords

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      References

        • World Health Organization
        The World Health Report 2002: Reducing the Risks, Promoting Healthy Life.
        World Health Organization, Geneva2002
        • King H.
        • Aubert R.E.
        • Herman W.
        Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections.
        Diabetes Care. 1998; 21: 1414-1431
        • Reddy K.S.
        • Yusuf S.
        Emerging epidemic of cardiovascular disease in developing countries.
        Circulation. 1998; 97: 596-601
        • Lakka H.M.
        • Laaksonen D.E.
        • Lakka T.A.
        • Niskanen L.K.
        • Kumpusalo E.
        • Tuomilehto J.
        • et al.
        The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men.
        JAMA. 2002; 288: 2709-2716
        • Kumar N.
        • Shekhar C.
        • Kumar P.
        • Kundu A.S.
        Kuppuswamy's socioeconomic status scale-updating for 2007.
        Indian J. Pediatr. 2007; 74: 1131-1132
      1. Cigarette Smoking Among Adults—United States, 2004.
        MMWR Morb. Mortal. Wkly. Rep. 2005; 54: 1121-1124
        • World Health Organization
        Global Physical Activity Questionnaire.
        World Health Organization, 2007 ([updated 2007 May; cited 2007 November]; available from: http://www.who.int/chp/steps/resources/GPAQ_Analysis_Guide.pdf)
      2. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III).
        JAMA. 2001; 285: 2486-2497
      3. The IDF Consensus Worldwide Definition of the Metabolic Syndrome.
        International Diabetes Federation, 2005 ([updated 2006; cited 2007 November 15]; available from: http://www.idf.org/webdata/docs/MetS_def_update2006.pdf)
        • Grundy S.M.
        • Cleeman J.I.
        • Daniels S.R.
        • Donato K.A.
        • Eckel R.H.
        • Franklin B.A.
        • et al.
        Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement.
        Circulation. 2005; 112: 2735-2752
        • Misra A.
        • Chowbey P.
        • Makkar B.M.
        • Vikram N.K.
        • Wasir J.S.
        • Chadha D.
        • et al.
        Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian Indians and recommendations for physical activity, medical and surgical management.
        J. Assoc. Physicians India. 2009; 57: 163-170
        • Ford E.S.
        Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the U.S..
        Diabetes Care. 2005; 28: 2745-2749
        • Meigs J.B.
        • Wilson P.W.F.
        • Nathan D.M.
        • D’Agostino R.B.
        • Williams K.
        • Haffner S.M.
        Prevalence and characteristics of the metabolic syndrome in the San Antonio Heart and Framingham Offspring studies.
        Diabetes. 2003; 52: 2160-2167
        • Tan C.E.
        • Ma S.
        • Wai D.
        • Chew S.K.
        • Tai E.S.
        Can we apply the National Cholesterol Education Program Adult Treatment Panel definition of the metabolic syndrome to Asians?.
        Diabetes Care. 2004; 27: 1182-1186
        • Anand S.S.
        • Yi Q.
        • Gerstein H.
        • Lonn E.
        • Jacobs R.
        • Vuksan V.
        • et al.
        Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease.
        Circulation. 2003; 108: 420-425
      4. Prevalence of the metabolic syndrome in populations of Asian origin. Comparison of the IDF definition with the NCEP definition.
        Diabetes Res. Clin. Pract. 2007; 76: 57-67
        • Misra K.B.
        • Endemann S.W.
        • Ayer M.
        Leisure time physical activity and metabolic syndrome in Asian Indian immigrants residing in northern California.
        Ethn. Dis. 2005; 15: 627-634
        • Tillin T.
        • Forouhi N.
        • Johnston D.G.
        • McKeigue P.M.
        • Chaturvedi N.
        • Godsland I.F.
        Metabolic syndrome and coronary heart disease in South Asians, African-Caribbeans and white Europeans: a UK population-based cross-sectional study.
        Diabetologia. 2005; 48: 649-656
        • Misra A.
        • Khurana L.
        Obesity and the metabolic syndrome in developing countries.
        J. Clin. Endocrinol. Metab. 2008; 93: S9-30
        • Ramachandran A.
        • Snehalatha C.
        • Satyavani K.
        • Sivasankari S.
        • Vijay V.
        Metabolic syndrome in urban Asian Indian adults—a population study using modified ATP III criteria.
        Diabetes Res. Clin. Pract. 2003; 60: 199-204
        • Ford E.S.
        • Giles W.H.
        • Dietz W.H.
        Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey.
        JAMA. 2002; 287: 356-359
        • Chandalia M.
        • Abate N.
        • Garg A.
        • Stray-Gundersen J.
        • Grundy S.M.
        Relationship between generalized and upper body obesity to insulin resistance in Asian Indian men.
        J. Clin. Endocrinol. Metab. 1999; 84: 2329-2335
        • Gupta R.
        • Deedwania P.C.
        • Gupta A.
        • Rastogi S.
        • Panwar R.B.
        • Kothari K.
        Prevalence of metabolic syndrome in an Indian urban population.
        Int. J. Cardiol. 2004; 97: 257-261
        • Misra A.
        • Pandey R.M.
        • Devi J.R.
        • Sharma R.
        • Vikram N.K.
        • Khanna N.
        High prevalence of diabetes, obesity and dyslipidaemia in urban slum population in northern India.
        Int. J. Obes. Relat. Metab. Disord. 2001; 25: 1722-1729
        • Singh R.
        • Bhansali A.
        • Sialy R.
        • Aggarwal A.
        Prevalence of metabolic syndrome in adolescents from a north Indian population.
        Diabet. Med. 2007; 24: 195-199
        • Ahlawat S.K.
        • Singh M.M.
        • Kumar R.
        • Kumari S.
        • Sharma B.K.
        Time trends in the prevalence of hypertension and associated risk factors in Chandigarh.
        J. Indian Med. Assoc. 2002; 100 (54–5, 72): 547-552
        • Park Y.W.
        • Zhu S.
        • Palaniappan L.
        • Heshka S.
        • Carnethon M.R.
        • Heymsfield S.B.
        The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988–1994.
        Arch. Intern. Med. 2003; 163: 427-436
        • Ma S.
        • Cutter J.
        • Tan C.E.
        • Chew S.K.
        • Tai E.S.
        Associations of diabetes mellitus and ethnicity with mortality in a multiethnic Asian population: data from the 1992 Singapore National Health Survey.
        Am. J. Epidemiol. 2003; 158: 543-552
        • Mohan V.
        • Shanthirani S.
        • Deepa R.
        • Premalatha G.
        • Sastry N.G.
        • Saroja R.
        Intra-urban differences in the prevalence of the metabolic syndrome in southern India—the Chennai Urban Population Study (CUPS No. 4).
        Diabet. Med. 2001; 18: 280-287
        • Ali O.
        • Tan T.T.
        • Sakinah O.
        • Khalid B.A.
        • Wu L.L.
        • Ng M.L.
        Prevalence of NIDDM and impaired glucose tolerance in aborigines and Malays in Malaysia and their relationship to sociodemographic, health, and nutritional factors.
        Diabetes Care. 1993; 16: 68-75
        • Abu Sayeed M.
        • Ali L.
        • Hussain M.Z.
        • Rumi M.A.
        • Banu A.
        • Azad Khan A.K.
        Effect of socioeconomic risk factors on the difference in prevalence of diabetes between rural and urban populations in Bangladesh.
        Diabetes Care. 1997; 20: 551-555
        • Kumar R.
        • Singh M.C.
        • Ahlawat S.K.
        • Thakur J.S.
        • Srivastava A.
        • Sharma M.K.
        • et al.
        Urbanization and coronary heart disease: a study of urban–rural differences in northern India.
        Indian Heart J. 2006; 58: 126-130
        • Hazuda H.P.
        • Haffner S.M.
        • Stern M.P.
        • Eifler C.W.
        Effects of acculturation and socioeconomic status on obesity and diabetes in Mexican Americans. The San Antonio Heart Study.
        Am. J. Epidemiol. 1988; 128: 1289-1301
        • Stern M.P.
        • Knapp J.A.
        • Hazuda H.P.
        • Haffner S.M.
        • Patterson J.K.
        • Mitchell B.D.
        Genetic and environmental determinants of type II diabetes in Mexican Americans. Is there a “descending limb” to the modernization/diabetes relationship?.
        Diabetes Care. 1991; 14: 649-654
        • Choiniere R.
        • Lafontaine P.
        • Edwards A.C.
        Distribution of cardiovascular disease risk factors by socioeconomic status among Canadian adults.
        CMAJ. 2000; 162: S13-24
        • Diez-Roux A.V.
        • Northridge M.E.
        • Morabia A.
        • Bassett M.T.
        • Shea S.
        Prevalence and social correlates of cardiovascular disease risk factors in Harlem.
        Am. J. Public Health. 1999; 89: 302-307
        • Ghosh A.
        Effects of socio-economic and behavioural characteristics in explaining central obesity—a study on adult Asian Indians in Calcutta, India.
        Coll. Antropol. 2006; 30: 265-271
        • Paeratakul S.
        • Popkin B.M.
        • Keyou G.
        • Adair L.S.
        • Stevens J.
        Changes in diet and physical activity affect the body mass index of Chinese adults.
        Int. J. Obes. Relat. Metab. Disord. 1998; 22: 424-431
        • Oldridge N.B.
        Economic burden of physical inactivity: healthcare costs associated with cardiovascular disease.
        Eur. J. Cardiovasc. Prev. Rehabil. 2008; 15: 130-139
        • Goyal A.
        • Yusuf S.
        The burden of cardiovascular disease in the Indian subcontinent.
        Indian J. Med. Res. 2006; 124: 235-244
        • Ramachandran A.
        • Snehalatha C.
        • Mohan V.
        • Viswanathan M.
        Development of carbohydrate intolerance in offspring of Asian Indian conjugal type 2 diabetic parents.
        Diabetes Res. Clin. Pract. 1990; 8: 269-273
        • Srinivasan S.R.
        • Frontini M.G.
        • Berenson G.S.
        Longitudinal changes in risk variables of insulin resistance syndrome from childhood to young adulthood in offspring of parents with type 2 diabetes: the Bogalusa Heart Study.
        Metabolism. 2003; 52 (discussion 51–3): 443-450
        • Anjana R.M.
        • Lakshminarayanan S.
        • Deepa M.
        • Farooq S.
        • Pradeepa R.
        • Mohan V.
        Parental history of type 2 diabetes mellitus, metabolic syndrome, and cardiometabolic risk factors in Asian Indian adolescents.
        Metabolism. 2009; 58: 344-350