Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus

Published:December 24, 2008DOI:


      Effects of glucomannan as a supplementary treatment in type 2 diabetes mellitus were investigated by measuring ghrelin, leptin and insulin responses to OGTT. Glucomannan enhanced prandial ghrelin reduction when given before glucose load and impeded the rise of fasting ghrelin after 4-week supplement. Ghrelin-induced feeding may be attenuated by glucomannan.


      To read this article in full you will need to make a payment


        • Higgins S.C.
        • Gueorguiev M.
        • Korbonits M.
        Ghrelin, the peripheral hunger hormone.
        Ann. Med. 2007; 39: 116-136
        • Meier U.
        • Gressner A.M.
        Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin.
        Clin. Chem. 2004; 50: 1511-1525
        • Anderwald C.
        • Brabant G.
        • Bernroider E.
        • et al.
        Insulin-dependent modulation of plasma ghrelin and leptin concentrations is less pronounced in type 2 diabetic patients.
        Diabetes. 2003; 52: 1792-1798
        • Erdmann J.
        • Lippl F.
        • Wagenpfeil S.
        • Schusdziarra V.
        Differential association of basal and postprandial plasma ghrelin with leptin, insulin, and type 2 diabetes.
        Diabetes. 2005; 54: 1371-1378
        • Wauters M.
        • Considine R.V.
        • Yudkin J.S.
        • Peiffer F.
        • De Leeuw I.
        • Van Gaal L.F.
        Leptin levels in type 2 diabetes: associations with measures of insulin resistance and insulin secretion.
        Horm. Metab. Res. 2003; 35: 92-96
        • Vuksan V.
        • Jenkins D.J.
        • Spadafora P.
        • et al.
        Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trial.
        Diabetes Care. 1999; 22: 913-919
        • Chearskul S.
        • Sangurai S.
        • Nitiyanant W.
        • Kriengsinyos W.
        • Kooptiwut S.
        • Harindhanavudhi T.
        Glycemic and lipid responses to glucomannan in Thais with type 2 diabetes mellitus.
        J. Med. Assoc. Thai. 2007; 90: 2150-2157
        • Katsuki A.
        • Urakawa H.
        • Gabazza E.C.
        • et al.
        Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus.
        Eur. J. Endocrinol. 2004; 151: 573-577
        • Cummings D.E.
        • Purnell J.Q.
        • Frayo R.S.
        • Schmidova K.
        • Wisse B.E.
        • Weigle D.S.
        A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans.
        Diabetes. 2001; 50: 1714-1719
        • Fruehwald-Schultes B.
        • Oltmanns K.M.
        • Kern W.
        • Born J.
        • Fehm H.L.
        • Peters A.
        The effect of experimentally induced insulin resistance on the leptin response to hyperinsulinaemia.
        Int. J. Obes. Relat. Metab. Disord. 2002; 26: 510-516