Abstract
Diabetic nephropathy is the major cause of end-stage renal disease. Many studies show
that chronic kidney disease can be prevented, or its progression to end-stage renal
disease delayed, by effective intervention. The aim of this study was to estimate
the prevalence of proteinuria and renal impairment in patients with type 2 diabetes.
A community-based screening for chronic kidney disease in type 2 diabetic patients
was conducted in 1999–2001. Proteinuria was defined in terms of urine protein-to-creatinine
ratio. The glomerular filtration rate per 1.73 m2 body surface area was calculated using an equation from the Modification of Diet
in Renal Disease Study. The overall response rate was about 78.6%. Prevalence rates
of proteinuria and renal impairment were 29.4% and 15.1%, respectively. Females had
higher prevalence of proteinuria and renal impairment than males. And prevalence increased
with increasing age. Hypertension was associated with both proteinuria and renal impairment.
Only 43.0% of patients with stages 3–5 chronic kidney disease had proteinuria. Proteinuria
and renal impairment screening may identify different segments of the diabetic population.
Both a glomerular filtration rate and proteinuria test are recommended as screening
tools for early detection of chronic kidney disease in type 2 diabetics.
Keywords
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Article info
Publication history
Published online: August 10, 2006
Accepted:
June 30,
2006
Received:
October 25,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
