Abstract
Background
To evaluate the efficacy of continuous glucose monitoring system (CGMS) to detect
postprandial hyperglycemia and unrecognized hypoglycemia in type 1 diabetes mellitus
(DM1) patients.
Methods
We studied 46 patients (43.4%M/56.6%F), average age of 25.9 ± 12.8 years, submitted to 72 h CGMS. It were analyzed: capillary glycemia (CG) and CGMS sensor's value, glycemic
excursions, postprandial hyperglycemia, asymptomatic hypoglycemia and therapeutic
management after CGMS. Correlation coefficient during hypo and hyperglycemia and sensitivity/specificity
were determined.
Results
The mean capillary glucose values were 191.8 ± 46.2 mg/dl versus 190.9 ± 42.1 mg/dl by CGMS sensor, with no statistical difference by T-test (T = −0.6; p = 0.79). The CGMS was significantly more efficient in detection of glycemic excursion
than CG (p = 0.001). The postprandial hyperglycemia was identified in 76.9% of diabetic patients
and asymptomatic hypoglycemia was detected in 58.2% of these patients. The correlation
coefficient presented no significance (p = 0.16) during hypoglycemia versus during hyperglycemia (p = 0.002). The CGMS sensor presented low sensitivity (79.1%) to detect hypoglycemia versus
hyperglycemia (96.8%).
Conclusions
The CGMS showed to be a good method to identify postprandial hyperglycemia, to improve
therapeutics management and confirmed the low sensitivity of CGMS to detect unrecognized
hypoglycemia in DM1 patients.
Keywords
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Article info
Publication history
Published online: June 28, 2006
Accepted:
May 12,
2006
Received:
September 9,
2005
Identification
Copyright
© 2006 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
