Abstract
Background: Oolong tea has been studied for its effect on cardiovascular disease and obesity.
Plasma adiponectin levels are reduced in obesity, in patients with type 2 diabetes
mellitus and in coronary artery disease (CAD). Objective: To investigate prospectively, whether intake of Oolong tea influences plasma adiponectin
levels, low-density lipoprotein (LDL) particle size, total cholesterol, high-density
lipoprotein (HDL) cholesterol, LDL cholesterol, serum triglyceride and plasma glucose
levels in patients with CAD. Methods: Twenty two patients in our study consumed Oolong tea (1000 ml) or water for 1 month in our randomized cross-over study design. Results: There was a significant difference in plasma adiponectin levels before and after
1 month intake of Oolong tea (6.26±3.26 μg/ml versus 6.88±3.28 μg/ml, P<0.05), and in plasma level LDL particle size (25.02±0.67 nm versus 25.31±0.60 nm, P<0.01). The water-consuming control group showed no changes (6.28±3.28 μg/ml versus 6.23±3.21 μg/ml) in adiponectin levels or LDL particle sizes (25.03±0.70 nm versus 25.02±0.72 nm). We also observed a significant difference in hemoglobin A1c levels (7.23±4.45%
versus 6.99±4.30%, P<0.05) before and after intake of Oolong tea. Conclusion: Oolong tea may have beneficial effects on the progression of atherosclerosis in patients
with CAD.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Diabetes Research and Clinical PracticeAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Effects of tea consumption on nutrition and health.J. Nutr. 2000; 130: 2409-2412
- Total antioxidant capacity of teas by the ferric reducing/antioxidant power assay.J. Agric. Food Chem. 1999; 47: 633-636
- Hypercholesterolemic effects of Chinese tea.Pharmacol. Res. 1997; 35: 505-512
- Anti-obesity action of Oolong tea.Int. J. Obes. Relat. Metab. Disord. 1999; 23: 98-105
- Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances.Ann. N.Y. Acad. Sci. 1999; 892: 146-154
- Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.Arterioscler. Thromb. Vasc. Biol. 2000; 20: 1595-1599
- Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.Circulation. 1999; 100: 2473-2476
- An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls.Horm. Metab. Res. 2000; 32: 47-50
- Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages.Circulation. 2001; 103: 1057-1063
- Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women.JAMA. 1996; 276: 875-881
- A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction.JAMA. 1996; 276: 882-888
- Fasting insulin and apolipoprotein B levels and low-density lipoprotein particle size as risk factors for ischemic heart disease.JAMA. 1998; 279: 1955-1961
- Role of plasma triglyceride in the regulation of plasma low density lipoprotein (LDL) sub-fractions: relative contribution of small, dense LDL to coronary heart disease risk.Atherosclerosis. 1994; 106: 241-253
The Fifth Report of the Joint National Committee on detection, evaluation, and treatment of high blood pressure (JNC V), Arch. Intern. Med. 153 (1993) 154–183.
Diabetes mellitus, Report of a WHO Study Group, World Health Organ. Tech. Rep. Ser. 727 (1985) 1–113.
- Antioxidant properties of fractions and polyphenol constituents from green, Oolong and black teas.Proc. Natl. Sci. Counc. 1993; 17: 77-84
- Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.Biochem. Biophys. Res. Commun. 1999; 257: 79-83
- Low-density lipoprotein subclass patterns and risk of myocardial infarction.JAMA. 1988; 260: 1917-1921
- Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signalling through a cAMP-dependent pathway.Circulation. 2000; 102: 1296-1301
- PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein.Diabetes. 2001; 50: 2094-2099
- Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice.Circulation. 2002; 106: 2767-2770
- Endothelial dysfunction in men with small LDL particles.Circulation. 2000; 102: 716-721
- Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B.Am. J. Med. 1993; 94: 350-356
- Apoprotein B structure and receptor recognition of triglyceride-rich low density lipoprotein (LDL) is modified in small LDL but not in triglyceride-rich LDL of normal size.J. Biol. Chem. 1994; 269: 511-519
- Conformational differences in human apolipoprotein B-100 among subspecies of low density lipoproteins (LDL). Association of altered proteolytic accessibility with decreased receptor binding of LDL subspecies from hypertriglyceridemic subjects.J. Biol. Chem. 1994; 269: 2912-2918
- Influence of plasma lipid and LDL-subfraction profile on the interaction between low density lipoprotein with human arterial wall proteoglycans.Atherosclerosis. 1996; 124: 261-271
- Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk.Circulation. 1990; 82: 495-506
- Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles.J. Clin. Invest. 1993; 92: 141-146
- Diet-induced insulin resistance in mice locking adiponectin/ACRP30.Nat. Med. 2002; 8: 731-737
- Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys.Diabetes. 2001; 50: 1126-1133
- Oolong tea increases metabolic rate and fat oxidation in men.J. Nutr. 2001; 131: 2848-2852
- Optimum hypoglycemic therapy can improve coronary flow velocity reserve in diabetic patients-demonstration by transthoracic Doppler echocardiography.Circ. J. 2003; 67: 945-950
Article info
Publication history
Published online: August 19, 2004
Accepted:
January 21,
2004
Received in revised form:
January 15,
2004
Identification
Copyright
© 2004 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
