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Effect of soluble fiber intake in lipid and glucose leves in healthy subjects: a randomized clinical trial

  • Rocio Aller
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • Daniel Antonio de Luis
    Correspondence
    Corresponding author. Fax: +34-98-3331566.
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • Olatz Izaola
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • Fernando La Calle
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • Lourdes del Olmo
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • Luis Fernandez
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • Teresa Arranz
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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  • J.M.Gonzalez Hernandez
    Affiliations
    Institute of Endocrinology and Nutrition, Medicine School and Hospital Rio Hortega, University of Valladolid, C/Los Perales 16 (URB Las Aceñas), Simancas, 47130 Valladolid, Spain
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      Abstract

      Objective: The aim of our work was to carry out a randomized clinical trial with two diets, one enriched in fiber (total fiber 30 g and soluble fiber 4 g) to investigate the effect on lipid and glucose levels in healthy subjects. Research design and methods: Fifty-three subjects were prospectively randomized to two groups (see Table 1). Group I received a diet with 10.4 g of fiber given as 1.97 g soluble fiber (pectins, gums and mucilages) and 8.13 g of insoluble fiber (hemicelullose, cellulose and lignins) and Group II received a diet with 30.5 g of fiber of which 4.11 g were soluble fiber and 25.08 g insoluble fiber. Prospective serial assessment of weight and nutritional intake (3 days written food records) were made. These determinations were performed at baseline and at 3 months. All enrolled subjects underwent the following examinations; fasting blood samples were drawn for measurement of total cholesterol, triglyceride concentrations and other lipid fractions, low density lipoprotein (LDL-cholesterol), high density lipoprotein (HDL-cholesterol), glucose, and insulin. Results: Total calorie and fat consumption were lower than recommended in both groups (calories; group I 1633±417 kcal per day versus group II 1707.5±579 kcal per day:ns) and (fats; group I 73.4±22.7 g per day versus group II 72.6±28 g per day:ns), without differences in fatty acid intake profile. Total fiber intake did not reach that recommended in both diets but it was higher in group II (9.06±2.7 g per day versus 25.95±7.12 g per day: P<0.05). Soluble fiber intake did not reach that recommended in both diets but it was higher in group II (1.7±0.58 g per day versus 3.5±0.96 g per day: P<0.05). Body weight did not change in both groups during treatment. During treatment, in group II a significant change was detected from baseline in LDL-cholesterol and fasting glucose levels. LDL-cholesterol decreased by 12.8% (P<0.05) and glucose decreased by 12.3% (P<0.05). No statistical differences were detected among triglycerides, HDL-cholesterol, and insulin levels. Conclusions: Modest increases in soluble fiber intake in healthy subjects improved LDL cholesterol and glucose levels.

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