Abstract
A 5-week pilot study was conducted to determine if continuous glucose monitoring could
be used to improve glycemic control. A total of nine subjects with type 1 diabetes
and HbA1c values greater than 8.5% completed the study. Subjects wore a continuous glucose
monitor for two 1-week periods during the study. After each sensor use, changes to
diet, insulin dosage and self-monitored blood glucose (SMBG) schedule were made. HbA1c decreased from 9.9% (S.D.=1.1%) at baseline to 8.8% (S.D.=1.0%) 5 weeks after baseline
(P=0.0006), but daily insulin usage was unchanged over the same period of time (P=0.428). The glucose sensors performed accurately, with a median correlation of 0.92
and a mean absolute difference of 19.1% (S.D.=9.0%). The continuous glucose profiles
allowed identification of glucose patterns and excursions that helped direct changes
in therapy. These treatment changes would not have been made on the basis of meter
data alone and were effective in improving glucose control. Additional studies are
needed to validate these findings. This pilot study highlights the potential for continuous
glucose monitoring to provide the valuable information necessary to make therapy adjustments
that can dramatically improve patients’ glycemic control and reduce the risk of long-term
complications.
Keywords
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References
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Article info
Publication history
Accepted:
September 17,
1999
Received in revised form:
September 17,
1999
Received:
September 13,
1999
Identification
Copyright
© 1999 Elsevier Science Ireland Ltd. Published by Elsevier Inc. All rights reserved.
ScienceDirect
Access this article on ScienceDirectLinked Article
- Erratum to “Continuous glucose monitoring used to adjust diabetes therapy improves glycosylated hemoglobin: a pilot study”: [Diabetes Res. Clin. Pract. 46 (1999) 183–190]Diabetes Research and Clinical PracticeVol. 47Issue 3
