Abstract
Aims
To assess passive smoking as a risk factor for developing type 2 Diabetes Mellitus
(T2DM).
Methods
A search of PubMed, Web of Knowledge, Elsevier ScienceDirect and Springer (up to March,
2014) databases were performed using subject and random words. Two authors independently
extracted the data. The Newcastle-Ottawa Scale (NOS) was used to assess the quality
of included studies. The odds ratio (ORs) for the association was determined using
a fix-effects model. Subgroup and sensitivity analyses were performed and publication
bias was assessed.
Result
7 prospective studies were included in this meta-analysis which included a total of
162,001 subjects. The overall OR for developing T2DM for passive smoking was 1.33
(95% confidence interval (CI) 1.20–1.46), with no significant heterogeneity between
studies. The result was stable in the subgroup and sensitivity analyses, however there
was evidence of publication bias. After the “fill and trim” method, the recalculated
OR was 1.27 (95%CI 1.16–1.40).
Conclusions
Passive smoking is a risk factor of T2DM even in those who were not themselves active
smokers.
Keywords
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Article info
Publication history
Published online: October 13, 2014
Accepted:
September 14,
2014
Received in revised form:
May 25,
2014
Received:
April 8,
2014
Identification
Copyright
© 2014 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
