Abstract
Background and aims
In this study, broccoli sprout powder (BSP), a good source of bioactive components,
was used as supplementary treatment in type 2 diabetic patients.
Methods
This randomized clinical trial included 81 patients with type 2 diabetes. Participants
were randomly assigned to consume 10 g/d BSP (group A), 5 g/d BSP (group B), or the placebo (group C), each for 4 weeks. Fasting blood glucose
(FBS), total cholesterol (TC), triglyceride concentration (TG), LDL-C, HDL-C, and
oxidized-LDL were measured at baseline and 4 weeks after treatment. The ratios of
OX-LDL/LDL, atherogenic index of plasma (AIP; log TG/HDL), TC/HDL and LDL/HDL were
calculated as cardiovascular risk factors parameters, at baseline and 4 weeks after
treatment.
Results
Seventy-two patients completed the study; n = 23, 26 and 23 for groups A, B and C, respectively. After 4 weeks, BSP in dose of 10 g/d, significantly decreased serum triglycerides, OX-LDL/LDL ratio and AIP (p < 0.05 for treatment effect). HDL-C concentration was significantly higher (p < 0.01 for treatment) in group A as compared with group B and placebo.
Conclusions
BSP as supplementary treatment in type 2 diabetes could have favorable effects on
lipid profiles and OX-LDL/LDL ratio, as risk factors for cardiovascular disease.
Keywords
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Article info
Publication history
Published online: February 13, 2012
Accepted:
January 3,
2012
Received in revised form:
December 15,
2011
Received:
July 18,
2011
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
