Abstract
Background and aims
In this study, broccoli sprout powder (BSP), a good source of bioactive components,
was used as supplementary treatment in type 2 diabetic patients.
Methods
This randomized clinical trial included 81 patients with type 2 diabetes. Participants
were randomly assigned to consume 10 g/d BSP (group A), 5 g/d BSP (group B), or the placebo (group C), each for 4 weeks. Fasting blood glucose
(FBS), total cholesterol (TC), triglyceride concentration (TG), LDL-C, HDL-C, and
oxidized-LDL were measured at baseline and 4 weeks after treatment. The ratios of
OX-LDL/LDL, atherogenic index of plasma (AIP; log TG/HDL), TC/HDL and LDL/HDL were
calculated as cardiovascular risk factors parameters, at baseline and 4 weeks after
treatment.
Results
Seventy-two patients completed the study; n = 23, 26 and 23 for groups A, B and C, respectively. After 4 weeks, BSP in dose of 10 g/d, significantly decreased serum triglycerides, OX-LDL/LDL ratio and AIP (p < 0.05 for treatment effect). HDL-C concentration was significantly higher (p < 0.01 for treatment) in group A as compared with group B and placebo.
Conclusions
BSP as supplementary treatment in type 2 diabetes could have favorable effects on
lipid profiles and OX-LDL/LDL ratio, as risk factors for cardiovascular disease.
Keywords
To read this article in full you will need to make a payment
Subscribe to Diabetes Research and Clinical Practice
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Dyslipidemia in type 2 diabetes mellitus.Curr Diab Rep. 2007; 7: 228-234
- Type 2 diabetes as a lipid disorder.Curr Mol Med. 2005; 5: 297-308
- Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose.Evid Rep Technol Assess. 2008; 12: 1-11
- Nutraceutical in diabetes and metabolic syndrome.Cardiovasc Ther. 2010; 28: 216-226
- Antioxidant phytochemicals against type 2 diabetes.Br J Nutr. 2008; 99: ES109-ES117
- Physiological effects of broccoli consumption.Phytochem Rev. 2009; 8: 283-298
- Chemoprevention by isothiocyanates and underlying molecular signaling mechanisms.Mutat Res. 2004; 555: 191-192
- Glucosinolates in brassica vegetable: the influence of the food supply chain on intake, bioavailability and human health.Mol Nutr Food Res. 2009; 53: S219-S266
- Effect of broccoli sprouts on cholesterol-lowering and anti-obesity effects in rats fed high fat diet.J Korean Soc Food Sci Nutr. 2009; 38: 309-318
- Chemical and biological characterisation of nutraceutical compounds of broccoli.J Pharm Biochem Anal. 2006; 41: 1508-1522
- Oral sulforaphane increases phase II antioxidant enzymes in the human upper airway.Clin Immunol. 2009; 130: 244-251
- Antioxidant function of sulforaphane: a potent inducer of phase 2 detoxyfication enzymes.Food Chem Toxicol. 1999; 37: 973-979
- Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts.Biofactors. 2004; 22: 271-275
- CONSORT 2010 statement. Updated guidelines for reporting parallel group randomized trials.J Clin Epidemiol. 2010; 63: 834-840
The Nutrient Data Laboratory. Food Composition Table (FCT), Food and Nutrition Information Center, United State Department of Agriculture (USDA). www.nal.usda.gov/fnic/foodcomp.
- Food composition table of Iran. National Nutrition and Food Research Institute.Shahid Beheshti University Press, 1980
- Comparison of LDL-cholesterol direct measurement with the estimate using the friedewald formula in a sample of 10664 patients.Arq Bras Cardiol. 2004; 83: 482-487
- Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies.Circulation. 2007; 115: 450-458
- Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies.J Cardiovasc Risk. 1996; 3: 213-219
- Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association.Diabetes Care. 2007; 30: 162-172
- Management of hypertriglyceridemia in the diabetic patient.Curr Diab Rep. 2010; 10: 316-320
- Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials.J Am Coll Cardiol. 2005; 45: 185-197
- Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial.Lancet. 2004; 364: 685-696
- Predictive value of circulating oxidized LDL for cardiac events in type 2 diabetic patients with coronary artery disease.Diabetes Care. 2004; 27: 843-844
- Effect of insulin treatment on plasma oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients.Diabetes Metab. 2006; 32: 625-631
- The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apo-B-lipoprotein-depleted plasma.Clin Biochem. 2001; 34: 583-588
- Fractional esterification rate of cholesterol and ratio of triglyceride to HDL-C are powerful predictors of positive finding on coronary angiography.Clin Chem. 2003; 49: 1873-1880
- Association of total cholesterol/high-density lipoprotein cholesterol ratio with proximal coronary atherosclerosis detected by multislice computed tomography.Prev Cardiol. 2009; 12: 19-26
- Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension.PLoS One. 2010; 5: e12461
- In vitro binding of bile acids by spinach, kale, brusseles sprouts, broccoli, mustard green, green bell pepper, cabbage and collards.Food Chem. 2007; 100: 1531-1536
- Hypocholesterolemic properties of plant indoles. Inhibition of acyl-CoA:cholesterol acyltransferase activity and reduction of serum LDL/VLDL cholesterol levels by glucobrassicin derivatives.Biochem Pharmacol. 1994; 47: 359-364
- Effect of the plant compound indole-3-carbinol on hepatic cholesterol homoeostasis.Food Chem Toxicol. 1994; 32: 633-639
- Cruciferous indole-3-carbinol inhibits apolipoprotein B secretion in HepG2 cells.J Nutr. 2007; 137: 2185-2189
- Comparison of coenzyme Q10 plasma levels in obese and normal weight children.Clin Chim Acta. 2004; 349: 121-127
- Dietary approach to attenuate oxidative stress, hypertension, and inflammation in the cardiovascular system.Proc Natl Acad Sci. 2004; 101: 7094-7099
- Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report.Dig Dis Sci. 2004; 49: 1088-1090
Article Info
Publication History
Published online: February 13, 2012
Accepted:
January 3,
2012
Received in revised form:
December 15,
2011
Received:
July 18,
2011
Identification
Copyright
© 2012 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
