Abstract
Aims
To identify better cells for the treatment of diabetic critical limb ischemia (CLI)
and foot ulcer in a pilot trial.
Methods
Under ordinary treatment, the limbs of 41 type 2 diabetic patients with bilateral
CLI and foot ulcer were injected intramuscularly with bone marrow mesenchymal stem
cells (BMMSCs), bone marrow-derived mononuclear cells (BMMNCs), or normal saline (NS).
Results
The ulcer healing rate of the BMMSC group was significantly higher than that of BMMNCs
at 6 weeks after injection (P = 0.022), and reached 100% 4 weeks earlier than BMMNC group. After 24 weeks of follow-up,
the improvements in limb perfusion induced by the BMMSCs transplantation were more
significant than those by BMMNCs in terms of painless walking time (P = 0.040), ankle-brachial index (ABI) (P = 0.017), transcutaneous oxygen pressure (TcO2) (P = 0.001), and magnetic resonance angiography (MRA) analysis (P = 0.018). There was no significant difference between the groups in terms of pain relief
and amputation and there was no serious adverse events related to both cell injections.
Conclusions
BMMSCs therapy may be better tolerated and more effective than BMMNCs for increasing
lower limb perfusion and promoting foot ulcer healing in diabetic patients with CLI.
Abbreviations:
CLI (critical limb ischemia), PAD (peripheral arterial disease), BMMSCs (bone marrow mesenchymal stem cells), BMMNCs (bone marrow-derived mononuclear cells), NS (normal saline), ABI (ankle-brachial index), TcO2 (transcutaneous oxygen pressure), MRA (magnetic resonance angiography)Keywords
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Article info
Publication history
Published online: January 10, 2011
Accepted:
December 6,
2010
Received in revised form:
October 19,
2010
Received:
September 10,
2010
Identification
Copyright
© 2010 Elsevier Ireland Ltd. Published by Elsevier Inc. All rights reserved.
