Diabetes Research and Clinical Practice
Volume 91, Issue 2 , Pages 129-137, February 2011

Diabetes and sleep: A complex cause-and-effect relationship

  • Mark T.U. Barone

      Affiliations

    • Instituto de Ciências Biomédicas, Universidade de São Paulo (ICB-USP), Brazil
    • Corresponding Author InformationCorresponding author at: Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo (ICB-USP), Av. Prof. Lineu Prestes, 1524 (ICB I), Cidade Universitária, 05508-900, São Paulo/SP, Brazil. Tel.: +55 11 3717 1997; fax: +55 11 3091 7254.
    • ,
  • Luiz Menna-Barreto

      Affiliations

    • Escola de Artes, Ciências e Humanidades, Universidade de São Paulo (EACH-USP), Brazil

Received 12 May 2010; received in revised form 26 July 2010; accepted 29 July 2010. published online 01 September 2010.

Abstract 

Strong associations of diabetes with sleep impairment have been frequently reported. In the present review, we discuss current evidence and hypotheses for how type 1 and type 2 diabetes mellitus are associated with sleep impairment. This association may be described as a vicious circle, where sleep disorders favor the development of type 2 diabetes or exacerbate the metabolic control of both types of diabetes, whereas diabetes itself, especially when associated with poor metabolic control, is often followed by sleep disorders. In this review, novel findings concerning the neuro-endocrine-metabolic mediation of the mentioned circle are highlighted. Understanding how this association occurs, the impact of sleep impairment on diabetes, and the impact of diabetes on the development or exacerbation of sleep disorders should lead to potential new therapeutic strategies for treating both conditions.

Keywords: Diabetes mellitus, Sleep disorders, Sleep quality, Sleep deprivation, Obstructive sleep apnea

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PII: S0168-8227(10)00388-8

doi:10.1016/j.diabres.2010.07.011

Diabetes Research and Clinical Practice
Volume 91, Issue 2 , Pages 129-137, February 2011

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