Diabetes Research and Clinical Practice
Volume 90, Issue 2 , Pages 196-201 , November 2010

Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus

  • D.A. Jones

      Affiliations

    • Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 0 1792 295073; fax: +44 0 1792 602147.
    • ,
  • S.L. Prior

      Affiliations

    • Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UK
    • ,
  • T.S. Tang

      Affiliations

    • Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UK
    • ,
  • S.C. Bain

      Affiliations

    • Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UK
    • ,
  • S.J. Hurel

      Affiliations

    • Department of Diabetes & Endocrinology, UCL Hospitals, London W1T 3AA, UK
    • ,
  • S.E. Humphries

      Affiliations

    • Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free & University College London Medical School, London WC1E 6JF, UK
    • ,
  • J.W. Stephens

      Affiliations

    • Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UK

Received 21 April 2010 ,Revised 19 July 2010 ,Accepted 22 July 2010.

References 

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  2. Stephens JW, Gable DR, Hurel SJ, Miller GJ, Cooper JA, Humphries SE. Increased plasma markers of oxidative stress are associated with coronary heart disease in males with diabetes mellitus and with 10-year risk in a prospective sample of males. Clin Chem. 2006;52:446–452
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  8. Kang D, Lee KM, Park SK, Berndt SI, Peters U, Reding D, et al. Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study. Cancer Epidemiol Biomarkers Prev. 2007;16:1581–1586
  9. Zejnilovic J, Akev N, Yilmaz H, Isbir T. Association between manganese superoxide dismutase polymorphism and risk of lung cancer. Cancer Genet Cytogenet. 2009;189:1–4
  10. Chistyakov DA, Savost’anov KV, Zotova EV, Nosikov VV. Polymorphisms in the Mn-SOD and EC-SOD genes and their relationship to diabetic neuropathy in type 1 diabetes mellitus. BMC Med Genet. 2001;2:4
  11. El Masry TM, Abou Zahra MAM, El Tawil MM, Khalifa RA. Managanese superoxide dismutase Alanine to Valine polymorphism and risk of neuropathy and nephropathy in Egyptian type 1 diabetic patients. Rev Diabetic Stud. 2005;2:70–74
  12. Lee SJ, Choi MG, Kim DS, Kim TW. Manganese superoxide dismutase gene polymorphism (V16A) is associated with stages of albuminuria in Korean type 2 diabetic patients. Metabolism. 2006;55:1–7
  13. Lee SJ, Choi MG. Association of manganese superoxide dismutase gene polymorphism (V16A) with diabetic macular edema in Korean type 2 diabetic patients. Metabolism. 2006;55:1681–1688
  14. Dhamrait SS, Stephens JW, Cooper JA, Acharya J, Mani AR, Moore K, et al. Cardiovascular risk in healthy men and markers of oxidative stress in diabetic men are associated with common variation in the gene for uncoupling protein 2. Eur Heart J. 2004;25:468–475
  15. Stephens JW, Hurel SJ, Acharya J, Humphries SE. An interaction between the interleukin-6-174G>C gene variant and urinary protein excretion influences plasma oxidative stress in subjects with type 2 diabetes. Cardiovasc Diabetol. 2004;3:2
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  18. Stephens JW, Humphries SE, Miller GJ, Cooper JA, Hurel SJ. Increased oxidative stress is associated with coronary heart disease in males with diabetes mellitus and with 10-year prospective risk in males without diabetes. Diabet Med. 2005;22(suppl. 2):P145
  19. Rothman KJ. No adjustments are needed for multiple comparisons. Epidemiology. 1990;1:43–46
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  22. Stephens JW, Ambler G, Vallance P, Betteridge DJ, Humphries SE, Hurel SJ. Cardiovascular risk and diabetes. Are the methods of risk prediction satisfactory?. Eur J Cardiovasc Prev Rehabil. 2004;11:521–528
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  24. Stephens JW, Bain SC, Humphries SE. Gene–environment interaction and oxidative stress in cardiovascular disease. Atherosclerosis. 2008;200:229–238

PII: S0168-8227(10)00386-4

doi: 10.1016/j.diabres.2010.07.009

Diabetes Research and Clinical Practice
Volume 90, Issue 2 , Pages 196-201 , November 2010

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