Diabetes Research and Clinical Practice
Volume 90, Issue 1 , Pages 66-72 , October 2010

Acceleration of diabetic wound healing by collagen-binding vascular endothelial growth factor in diabetic rat model

  • Xin Yan

      Affiliations

    • Department of Burns and Plastic Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    • These authors contributed equally to this work.
    • ,
  • Bing Chen

      Affiliations

    • Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100190, China
    • These authors contributed equally to this work.
    • ,
  • Yue Lin

      Affiliations

    • Department of Burns and Plastic Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    • ,
  • Yunjian Li

      Affiliations

    • Department of Burns and Plastic Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    • ,
  • Zhifeng Xiao

      Affiliations

    • Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100190, China
    • ,
  • Xianglin Hou

      Affiliations

    • Yantai Zhenghai Biotechnology Company, Ltd, Yantai, Shangdong 264006, China
    • ,
  • Qian Tan

      Affiliations

    • Department of Burns and Plastic Surgery, Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 025 83107044; fax: +86 025 83107044.
    • ,
  • Jianwu Dai

      Affiliations

    • Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 3 Nanyitiao, Zhongguancun, Beijing 100190, China
    • Corresponding Author InformationCorresponding author. Tel.: +86 010 82614426; fax: +86 010 82614426.

Received 31 March 2010 ,Revised 20 June 2010 ,Accepted 1 July 2010.

References 

  1. Goodridge D, Trepman E, Sloan J, Guse L, Strain LA, Mclntyre J, et al. Quality of life of adults with unhealed and healed diabetic foot ulcers. Foot Ankle Int. 2006;27(4):274–280
  2. Lobmann R, Schultz G, Lehnert H. Molecular fundamentals of wound healing in diabetic foot syndrome. Med Klin (Munich). 2003;98(5):292–301
  3. Galkowska H, Wojewodzka U, Olszewski WL. Chemokines, cytokines, and growth factors in keratinocytes and dermal endothelial cells in the margin of chronic diabetic foot ulcers. Wound Repair Regen. 2006;14(5):558–565
  4. Pradhan L, Nabzdyk C, Andersen ND, LoGerfo FW, Veves A. Inflammation and neuropeptides: the connection in diabetic wound healing. Expert Rev Mol Med. 2009;11:e2
  5. Wang Z, Zhang J, Zhang B. Vascular endothelial growth factor gene expression in patients’ ischemic skeletal muscle with diabetic foot. Chin J Surg. 2002;40(7):505–507
  6. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407:242–248
  7. Morykwas MJ, Argenta LC, Shelton Brown EI, McGuirt W. Vacuum assisted closure: a new method for wound control and treatment: animal studies and basic foundation [J]. Ann Plast Surg. 1997;38(6):553–562
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  9. Lu SL, Qin C, Xie T, Sai J. Research on factory mechanism of the cutaneous “underlying disorder” in diabetic rats [J]. Chin J Trauma. 2004;20(8):468–473
  10. Onodera H, Ikeuchi D, Nagayama S, Imamura M. Weakness of anastomotic site in diabetic rats is caused by changes in the integrity of newly formed collagen [J]. Dig Surg. 2004;21(2):146–151
  11. Jing Z, Liang D, Zhao YN, Sun WJ, Chen B, Lin H, et al. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction. Circulation. 2009;119:1776–1784
  12. Trousdale RK, Jacobs S, Simhaee DA, Wu JK, Lustbader JW. Wound closure and metabolic parameter variability in a db/db mouse model for diabetic ulcers. J Surg Res. 2009;151(1):100–107
  13. Frank S, Hubner G, Breier G, Longaker MT, Greenhalgh DG, Werner S. Regulation of vascular endothelial growth factor expression in cultured keratinocytes. Implications for normal and impaired wound healing [J]. J Biol Chem. 1995;270(21):12607–12613
  14. Howdieshell TR, Riegner C, Gupta V, Callaway D, Grembowicz K, Sathyanarayana , et al. Normoxic wound fluid contains high levels of vascular endothelial growth factor[J]. Ann Surg. 1998;228(5):707–715
  15. Zhang F, Liu H, Stile F, Lei MP, Pang Y, Oswald TM, et al. Effect of vascular endothelial growth factor on rat Achilles tendon healing[J]. Plast Reconstr Surg. 2003;112(6):1613–1619
  16. Zhu XD, Zhang Y, Hu CX, Wang ZG. Study on the molecular mechanisms involved in the increased collagen synthesis by platelet-derived wound healing factors during wound healing in alloxan-induced diabetic rat[J]. Chin J Reparative Reconstr Surg. 2001;15(4):223–226
  17. Hamed S, Ullmann Y, Masoud M, Hellou E, Khamaysi Z, Teot L, et al. Topical erythropoietin promotes wound repair in diabetic rats[J]. J Invest Dermatol. 2010;130:287–294

PII: S0168-8227(10)00356-6

doi: 10.1016/j.diabres.2010.07.001

Diabetes Research and Clinical Practice
Volume 90, Issue 1 , Pages 66-72 , October 2010

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